产品名称
抗胶质纤维酸性蛋白 兔抗, IgG fraction of antiserum, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, human
packaging
antibody small pack of 25 μL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:80 using brain sections
microarray: suitable
western blot: 1:500 using brain extract
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GFAP(2670)
rat ... Gfap(24387)
Application
兔抗胶质纤维酸性蛋白抗体适用于：
- 使用大鼠脑切片进行 1:400 工作稀释度的免疫组织化学染色
- 人脑肿瘤组织标本免疫组织化学染色鉴定表达 AQP4 (Aquaporin-4) 的细胞
- 使用小鼠脑切片的免疫荧光法
Biochem/physiol Actions
神经胶质纤维酸性蛋白在中枢神经系统发育过程中可用作区分星形胶质细胞与其他神经胶质细胞的标记物。GFAP负责维持胶质细胞的结构。它还为周围的神经元和血脑屏障提供机械强度和支持。该基因的缺陷会导致亚历山大病，表现为罗森塔尔纤维的沉积。它是罕见的中枢神经系统星形胶质细胞功能紊乱。GFAP表达增加表示星形胶质细胞增生，是神经退行性和神经炎症的病征。
该产物与 GFAP 特异性反应，并在免疫组织化学染色中标记星形胶质细胞，神经胶质细胞和胶质细胞衍生的肿瘤。该抗体在酒精或福尔马林固定、石蜡包埋的人或动物组织切片中与神经胶质特异性抗原反应。
Disclaimer
除非我们的产品目录或产品随附的其他公司文件中另有说明，否则我们的产品仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途或任何类型的人类或动物消费或应用。
General description
GFAP（神经胶质纤维酸性蛋白）基因编码一种中间蛋白纤维-III（50kDa）。它分别位于中枢和外周神经系统的星形胶质细胞和非髓鞘雪旺氏细胞。
Immunogen
来自人类大脑的 GFAP
Physical form
0.01 M 磷酸盐缓冲液 (pH 7.4) 中的溶液，含 15 mM 叠氮化钠
Preparation Note
其在 2-8°C 条件下至多储存 1 个月。对于长期储存，溶液可以工作等份冷冻。不建议反复冻融或储存在“无霜”冰柜中。如果延长储存时间后出现轻微浑浊，使用前离心澄清。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
常规特殊物品
此项目有
S Saadoun et al.
Journal of neurology, neurosurgery, and psychiatry, 72(2), 262-265 (2002-01-18)
Aquaporin-4 (AQP4) is a highly conserved water channel protein. In rats, AQP4 is expressed in astrocyte foot processes and is important in brain water homeostasis. AQP4 expression has not been investigated in non-neoplastic human brain or oedematous brain tumours, where
Induction of glial fibrillary acidic protein expression in astrocytes by nitric oxide
Brahmachari S, et al.
The Journal of Neuroscience, 26(18), 4930-4939 (2006)
Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker
Yang Z and Wang K K
Trends in Neurosciences, 38(6), 364-374 (2015)
Dana M Niedowicz et al.
Acta neuropathologica communications, 2, 64-64 (2014-06-12)
Mid-life obesity and type 2 diabetes mellitus (T2DM) confer a modest, increased risk for Alzheimer's disease (AD), though the underlying mechanisms are unknown. We have created a novel mouse model that recapitulates features of T2DM and AD by crossing morbidly
David Piccin et al.
Stem cells (Dayton, Ohio), 29(3), 528-538 (2011-03-23)
Neural stem cells comprise a small population of subependymal cells in the adult brain that divide asymmetrically under baseline conditions to maintain the stem cell pool and divide symmetrically in response to injury to increase their numbers. Using in vivo
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