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Merck
CN

HPA001383

抗-ERBB2 兔抗

Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

别名:

抗-CD340, 抗-HER-2, 抗-HER2, 抗-NEU, 抗-NGL, 抗-ERBB2

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关于此项目

UNSPSC Code:
12352203
Human Protein Atlas Number:
HPA001383
NACRES:
NA.41
MDL number:
MFCD00239647

主要文件

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产品名称

抗-ERBB2 兔抗, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

technique(s)

immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:500-1:1000

immunogen sequence

LPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTA

UniProt accession no.

P04626

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... ERBB2(2064)

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相关类别

Application

成功使用该抗体的应用以及相关的同行评审论文如下所示。
蛋白质印迹（1篇论文）

Biochem/physiol Actions

酪氨酸蛋白激酶erbB-2受体是由ERBB2基因编码的蛋白质酪氨酸激酶。它属于表皮生长因子（EGF）受体家族。该蛋白质缺乏配体结合结构域，并需要用于结合配体的辅助受体。它通过与环氧合酶 COX-2 基因启动子结合而起到转录调节剂的作用。已经在包括乳腺癌和卵巢癌在内的多种癌症中观察到该基因的过度表达。ErbB-2 增强 EGF 和 NDF 诱导的其它 ErbB 家族受体酪氨酸激酶的酪氨酸磷酸化。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

Features and Benefits

Prestige Antibodies®是经过高度表征和广泛验证的抗体，同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige Antibodies®对其他蛋白质的独特性和低交叉反应性是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。每种Prestige 抗体都有相应的Prestige 抗原对照品，可在链接部分找到。

每种Prestige 抗体的检测方法如下：
  • 44种正常人体组织和20种最常见癌症组织的IHC组织阵列。
  • 364个人重组蛋白片段的蛋白阵列。

Immunogen

erb-b2受体酪氨酸激酶2

Other Notes

相应抗原APREST79717

Physical form

磷酸盐缓冲盐水溶液，pH 7.2，含有40%甘油和0.02%叠氮化钠

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

常规特殊物品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
000007298
000022602
A69483
R00270
A01762

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G M Seigel et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 37(5), 6135-6142 (2015-11-29)
Retinoblastoma (RB) is an ocular malignancy of early childhood. Although mutations in the Rb1 gene and expression of stem cell markers have been identified in RB, additional information on RB-specific alterations in signaling pathways and protein expression would be useful
David Cordeiro Sousa et al.
Ocular oncology and pathology, 3(3), 210-215 (2017-12-13)
Retinoblastoma (RB) is the most common primary intraocular malignancy. Current therapies are associated with high morbidity in the short- and long-term. Human epidermal growth factor receptor 2 (HER2) is a transmembrane protein detected in 15-30% of breast cancers, but it
Hee Jin Lee et al.
American journal of clinical pathology, 142(6), 755-766 (2014-11-13)
Heterogeneity of HER2 gene amplification is found in a subset of breast cancers. We investigated the impact of HER2 heterogeneity on trastuzumab responses and clinical outcomes in 112 patients with HER2-positive metastatic breast cancer. Regional and genetic heterogeneity of HER2
Gail M Seigel et al.
Oncoscience, 6(7-8), 357-366 (2019-10-15)
Retinoblastoma (RB) is an ocular tumor of early childhood. Current treatments attempt to preserve visual function, but may spare chemoresistant tumor cells. One potential therapeutic target for RB is HER2, (ERBB2), expressed in RB in truncated form. In this study
R Vadlamudi et al.
Oncogene, 18(2), 305-314 (1999-02-02)
Emerging lines of evidence suggest that in addition to growth factors, the process of colorectal tumorigenesis may also be driven by the upregulation of the inducible form of cyclooxygenase-2 (COX-2), an enzyme responsible for the conversion of arachidonic acid to
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