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Merck
CN

M5308

L-Methionine

99.0-101.0%, suitable for cell culture, BioXtra, non-animal source

Synonym(s):

(S)-2-Amino-4-(methylmercapto)butyric acid, L-2-Amino-4-(methylthio)butanoic acid

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About This Item

Linear Formula:
CH3SCH2CH2CH(NH2)CO2H
CAS Number:
63-68-3
Molecular Weight:
149.21
NACRES:
NA.26
PubChem Substance ID:
24896818
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
200-562-9
MDL number:
MFCD00063097
Beilstein/REAXYS Number:
1722294

Key Documents

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Product Name

L-Methionine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 99.0-101.0%

InChI key

FFEARJCKVFRZRR-BYPYZUCNSA-N

InChI

1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1

SMILES string

CSCC[C@H](N)C(O)=O

biological source

non-animal source

agency

USP/NF
meets EP testing specifications
meets JP testing specifications
meets USP testing specifications

product line

BioXtra

assay

99.0-101.0%

form

powder

quality

meets EP, JP, USP testing specifications

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

mp

284 °C (dec.) (lit.)

solubility

H2O: 25 mg/mL

application(s)

peptide synthesis
pharmaceutical (small molecule)

Quality Level

300

Gene Information

rat ... Ggt1(116568)

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Application

L-Methionine has been used as a component of media to culture various cancer cells and to study its effects on the cell cycle. It has also been used as a component of DMEM medium to culture satellite cells from the white muscle of trouts.

Biochem/physiol Actions

Methionine is an essential amino acid which acts a precursor for transmethylation and transsulphuration. In proteins, L-methionine is the biologically active form. The adenosylation of methionine results in the formation of S-adenosyl-L-methionine (SAM), which serves as a methyl donor to various substances. L-Methionine′s metabolic product glutathione is known to regulate immune response and has antiviral action.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000511013
0000510964
0000510965
0000510964
0000510965

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L-methionine as immune supportive supplement: a clinical evaluation.
Van Brummelen
Amino Acids, 33(1) (2007)
Suppression by L-Methionine of Cell Cycle Progression in LNCaP and MCF-7 Cells but not Benign Cells
Maximo A
Anticancer Research (2010)
miR-210 expression is associated with methionine-induced
differentiation of trout satellite cells
Mary Latimer
The Journal of Experimental Biology (2017)
Bio-Methionine Production from Glucose - Cost Analysis - Methionine E31A (2016)
Chien-Kuang Cornelia Ding et al.
Nature metabolism, 2(3), 270-277 (2020-05-29)
Critical to the bacterial stringent response is the rapid relocation of resources from proliferation toward stress survival through the respective accumulation and degradation of (p)ppGpp by RelA and SpoT homologues. While mammalian genomes encode MESH1, a homologue of the bacterial
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