PRS2325
Anti-CASPASE-12 (ab1) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Casp-12
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 46 kDa
species reactivity
rat, mouse, human
technique(s)
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
mouse ... Casp12(12364)
General description
Caspase 12 (CASP12), a member of the caspase family, is expressed in the Golgi complex.
Immunogen
a peptide corresponding to amino acids 2-17 of murine caspase-12.
Application
Anti-CASPASE-12 (ab1) antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
Murine caspase 12 (CASP12) is activated during endoplasmic reticulum stress and activates other caspases which act on substrates, ultimately leading to apoptosis. The protein has been shown to be activated during progression of retinal degeneration in animal models. In mice models, CASP12 has been shown to cause neuronal death resulting from ischemia/reperfusion.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
Other Notes
The action of this antibody can be blocked using blocking peptide SBP2325.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Find documentation for the products that you have recently purchased in the Document Library.
Ameliorating effect of Klotho on endoplasmic reticulum stress and renal fibrosis induced by unilateral ureteral obstruction
Qi-Feng
Iranian Journal of Kidney Diseases (2015)
Targeting Caspase-12 to Preserve Vision in Mice With Inherited Retinal Degeneration
Yogesh B
Investigative Ophthalmology & Visual Science (2015)
Activation of caspase-12 by endoplasmic reticulum stress induced by transient middle cerebral artery occlusion in mice.
Shibata M
Neuroscience (2003)
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