PRS3985
Anti-Nicastrin (ab2) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-APH-2, Anti-Anterior pharynx defective 2, Anti-Nicastrin
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IF, IHC, WB
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, rat, mouse
technique(s)
immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... NCSTN(23385)
General description
Nicastrin (NCSTN) is a transmembrane glycoprotein, that is located on chromosome 1q23.
Immunogen
a 18 amino acid peptide from near the center of human Nicastrin.
Application
Anti-Nicastrin has been used in western blotting.
Biochem/physiol Actions
Nicastrin (NCSTN) helps in the assembly of γ-secretase complex. It is associated with Alzheimer′s disease.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3985.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample
Dermaut B, et al.
American Journal of Human Genetics, 70(6), 1568-1574 (2002)
Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta
Kuzuya A, et al.
BMC Biology, 14:25 (2016)
Akira Kuzuya et al.
BMC biology, 14, 25-25 (2016-04-03)
Synaptic loss strongly correlates with memory deterioration. Local accumulation of amyloid β (Aβ) peptide, and neurotoxic Aβ42 in particular, due to abnormal neuronal activity may underlie synaptic dysfunction, neurodegeneration, and memory impairments. To gain an insight into molecular events underlying
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