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SAB3500193

Anti-IRAK-M antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-ASRT5, Anti-IRAKM

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD03096977
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IF, IHC, WB
Citations:
6

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 66 kDa

species reactivity

rat, mouse, human

technique(s)

immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

NCBI accession no.

AF113136

UniProt accession no.

Q9Y616

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... IRAK3(11213)

Related Categories

General description

The IRAKM (interleukin-1 receptor-associated kinase-3) gene is mapped to human chromosome 12q14.3. This gene is predominantly expressed in monocytes and macrophages.

Immunogen

IRAK-M antibody was raised against a peptide corresponding to amino acids from the carboxy terminus of human IRAK-M .

Application

Anti-IRAK-M antibody produced in rabbit has been used in Western blotting, immunoprecipitation and immunofluorescence.

Biochem/physiol Actions

The Irakm (interleukin-1 receptor-associated kinase-3) protein downregulates the toll like receptor (TLR)-signalling and influences the action of nuclear factor-κB (NF-κB). Increased IRAKM expression is observed in inflammatory bowel disease (IBD) and colorectal cancer. It is known to reduce the immune response against microorganism.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied in PBS with 0.02% sodium azide.

Other Notes

The action of this antibody can be blocked using blocking peptide SBP3500193.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
低风险生物材料
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Certificates of Analysis (COA)

Lot/Batch Number
23550601

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Implication of the toll-like receptor 4 pathway in the response to interferon-beta in multiple sclerosis
Bustamante MF, et al.
Annals of Neurology, 70(4), 634-645 (2011)
Enhanced mucosal defense and reduced tumor burden in mice with the compromised negative regulator IRAK-M
Rothschild DE, et al.
EBioMedicine, 15(1), 36-47 (2017)
Confirmation of an IRAK3 polymorphism as a genetic marker predicting response to anti-TNF treatment in rheumatoid arthritis
Sode J, et al.
Pharmacogenomics, 18(1), 81-81 (2018)
The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation
Nechama M, et al.
Nature Communications, 9(1), 1603-1603 (2018)
Interleukin-1 receptor-associated kinase 3 gene associates with susceptibility to acute lung injury
Pino Yanes M, et al.
American Journal of Respiratory Cell and Molecular Biology, 45(4), 740-745 (2011)
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