SAB3500318
Anti-TMEM16A antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Ano1, Anti-Anoctamin 1, Anti-Calcium activated chloride channel, Anti-DOG1, Anti-TAOS1
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, human
technique(s)
indirect ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ANO1(55107)
General description
Transmembrane member 16A (TMEM16A) or Anoctamin1 (Ano1) is a calcium-activated chloride channel. It is expressed in the interstitial cells of Cajal (ICC) in the gastrointestinal tract. The gene encoding this protein is localized on human chromosome 11q13.3.
Immunogen
TMEM16A antibody was raised against a 17 amino acid peptide from near the amino terminus of human TMEM16A.
Biochem/physiol Actions
Transmembrane member 16A (TMEM16A) or Ano1 is crucial for normal electrical slow waves and for the proliferation of interstitial cells of Cajal (ICC). The protein has a role in smooth muscle contraction, salivary secretion and cardiac and neuronal excitability. TMEM16A has been associated with head and neck squamous cell carcinoma and breast cancer.
Features and Benefits
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Physical form
Supplied in PBS with 0.02% sodium azide.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3500318.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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EAVK segment "c" sequence confers Ca2+-dependent changes to the kinetics of full-length human Ano1.
Strege PR
American Journal of Physiology: Gastrointestinal and Liver Physiology (2017)
GDD1 Is Identical to TMEM16E, a Member of the TMEM16 Family
Masuko K
American Journal of Human Genetics (2004)
TMEM16A/ANO1 suppression improves response to antibody-mediated targeted therapy of EGFR and HER2/ERBB2.
Kulkarni S
Genes Chromosomes Cancer (2017)
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