SAB3500536
Anti-HVCN1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-HV1, Anti-Hydrogen voltage-gated channel 1, Anti-VSOP, Anti-Voltage sensor domain-only protein
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IF, IHC, WB
Citations:
6
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 30 kDa
species reactivity
rat, human, mouse
technique(s)
immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HVCN1(84329)
General description
Hydrogen voltage gated channel 1 (HVCN1) is a voltage gated proton channel and is needed for efflux of intracellular acid. The gene encoding it is localized on human chromosome 12q24.11.
Immunogen
HVCN1 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human HVCN1.
Biochem/physiol Actions
Hydrogen voltage gated channel 1 (HVCN1) modulates insulin secretion by participating in Ca2+ homeostasis. In mice, the channel is involved in superoxide generation, bacterial removal from granulocytes and neutrophils and superoxide-associated B-cell receptor (BCR) signaling. HVCN1 might be associated with BCR-mediated B-cell malignancies.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied in PBS with 0.02% sodium azide.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3500536.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
The voltage-gated proton channel Hv1 is expressed in pancreatic islet ?-cells and regulates insulin secretion.
Zhao Q
Biochemical and Biophysical Research Communications (2015)
Hv1 proton channel opening is preceded by a voltage-independent transition.
Villalba-Galea CA
Biophysical Journal (2014)
Voltage-Gated Proton Channels as Novel Drug Targets: From NADPH Oxidase Regulation to Sperm Biology
Tamara S
Antioxidants & Redox Signaling (2015)
Enhanced activation of an amino-terminally truncated isoform of the voltage-gated proton channel HVCN1 enriched in malignant B cells.
Hondares E
Proceedings of the National Academy of Sciences of the USA (2014)
Padraig Hawkins et al.
Medicina (Kaunas, Lithuania), 57(8) (2021-08-28)
Background and Objectives: Alpha-1 antitrypsin is a serine protease inhibitor that demonstrates an array of immunomodulatory functions. Individuals with the genetic condition of alpha-1 antitrypsin deficiency (AATD) are at increased risk of early onset emphysematous lung disease. This lung disease
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