SAB4700040
单克隆抗-CD3 小鼠抗
clone OKT3, purified immunoglobulin, buffered aqueous solution
别名:
Mouse Anti-T-cell surface antigen T3/Leu-4 epsilon chain, Mouse Monoclonal Anti-T3E
产品名称
单克隆抗-CD3 小鼠抗, clone OKT3, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
OKT3, monoclonal
form
buffered aqueous solution
species reactivity
human
concentration
1 mg/mL
technique(s)
flow cytometry: suitable
isotype
IgG2a
NCBI accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CD3(916)
Features and Benefits
完放心地使用我们的抗体。如果抗体在您的申请的研究中不起作用，我们将全额退款或安排替代抗体。了解更多信息。
General description
CD3基因定位于人类染色体11q23.3。编码的蛋白质以CD3ε、CD3γ和CD3δ三种亚型形式存在，每个都包含一个N端胞外域、一个跨膜片段和一个胞质域。CD3 是在所有人 T 淋巴细胞表面表达的 20kDa 糖蛋白。
小鼠单克隆抗体OKT3可识别成熟人T细胞上TCR/CD3复合物的CD3抗原。该抗体也称为Orthoclone OKT3或Muromonab-CD3，已被广泛用作治疗同种异体肾移植、心脏移植和肝脏移植的急性、糖皮质激素耐药性排斥反应的药物。还研究了其用于治疗T细胞急性淋巴细胞白血病的用途。
Application
小鼠抗CD3单克隆抗体可用于增殖试验。
该试剂专为流式细胞术分析而设计。推荐工作稀释度为1 μg/mL样品。标示稀释度是本品的推荐稀释起点。工作浓度应由研究者确定。
Biochem/physiol Actions
包含CD3ε、CD3γ和CD3δ的T细胞受体CD3复合物，在诱导导致T细胞活化的早期代谢事件中起关键性作用。在T-B+ NK+严重合并免疫缺陷症（SCID）患者中观察到了CD3ε突变。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Physical form
溶于磷酸盐缓冲液，pH 7.4，含有15 mM叠氮化钠。
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Stephanie M Stanford et al.
Immunology, 137(1), 1-19 (2012-08-07)
More than half of the known protein tyrosine phosphatases (PTPs) in the human genome are expressed in T cells, and significant progress has been made in elucidating the biology of these enzymes in T-cell development and function. Here we provide
Reem Berro et al.
Journal of virology, 85(16), 8227-8240 (2011-06-18)
Resistance to small-molecule CCR5 inhibitors arises when HIV-1 variants acquire the ability to use inhibitor-bound CCR5 while still recognizing free CCR5. Two isolates, CC101.19 and D1/85.16, became resistant via four substitutions in the gp120 V3 region and three in the
Myeloid-derived suppressor cells suppress CD4+ and CD8+ T cell responses in autoimmune hepatitis
Li H
Molecular Medicine Reports, 12, 3667-3673 (2015)
The T cell receptor/CD3 complex: a dynamic protein ensemble.
Clevers H
Annual Review of Immunology, 629-662 (1988)
Haiwen Li et al.
Molecular medicine reports, 12(3), 3667-3673 (2015-05-23)
Myeloid-derived suppressor cells (MDSCs) have been demonstrated with possess the ability to suppress T‑cell responses. Therefore, MDSCs are an attractive candidate for immune intervention aimed at reconstituting self‑tolerance in autoimmune conditions. The present study investigated the frequency and function of
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