SAB4700135
Monoclonal Anti-CD28 antibody produced in mouse
low endotoxin, clone CD28.2, purified immunoglobulin, buffered aqueous solution
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Product Name
Monoclonal Anti-CD28 antibody produced in mouse, low endotoxin, clone CD28.2, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
CD28.2, monoclonal
form
buffered aqueous solution
species reactivity
nonhuman primates, human
concentration
1 mg/mL
technique(s)
flow cytometry: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CD28(940)
Related Categories
Application
The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2-8 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
Biochem/physiol Actions
Cluster of differentiation 28 (CD28) antigen has a role in T-cell activation, proliferation, survival and function. It modulates thymic development, peripheral homeostasis and the suppressive functions of regulatory T cells. CD28 has a role in signal transduction and is involved in activating many adaptor proteins. Mutation in the gene increases the risk of susceptibility to rheumatoid arthritis.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Cluster of differentiation 28 (CD28) antigen is a co-stimulatory receptor expressed in naive T-cells.[52} It contains a short cytoplasmic tail and two proline-rich motifs. CD28 is encoded by the gene mapped to human chromosome 2q33.2.
Immunogen
DC28.1.3.3 hybridoma cells
Physical form
Solution in azide free phosphate buffered saline, pH 7.4; 0.2 um filter sterilized. Endotoxin level is less than 10 EU/mg of the protein, as determined by the LAL test.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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CTLA-4 and Not CD28 Is a Susceptibility Gene for Thyroid Autoantibody Production
Tomer Y
The Journal of Clinical Endocrinology and Metabolism, 86, 1687-1693 (2001)
Genetic variants at CD28, PRDM1, and CD2/CD58 are associated with rheumatoid arthritis risk
Raychaudhuri S
Nature Genetics, 41, 1313-1318 (2009)
Interrupting CD28 costimulation before antigen rechallenge affects CD8(+) T-cell expansion and effector functions during secondary response in mice.
Frohlich M
European Journal of Immunology, 46, 1644-1655 (2016)
Yuki Akieda et al.
Journal of immunology (Baltimore, Md. : 1950), 194(9), 4162-4174 (2015-04-01)
In patients receiving allogeneic hematopoietic cell transplantation, chronic graft-versus-host disease (cGVHD) remains a frequent complication and resembles autoimmune diseases such as systemic lupus erythematosus and systemic sclerosis. Our previous work demonstrated the critical role of CD28 costimulation of donor T
Cheryl H Rozanski et al.
Journal of immunology (Baltimore, Md. : 1950), 194(10), 4717-4728 (2015-04-03)
In health, long-lived plasma cells (LLPC) are essential for durable protective humoral immunity, and, conversely, in disease are a major source of pathogenic Abs in autoimmunity, graft rejection, and allergy. However, the molecular basis for their longevity is largely unknown.
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