Ready-To-Conjugate Purified Antibodies for Spatial Biology Applications

Purified antibodies have become an indispensable tool in spatial biology, aiding in the characterization of cellular and molecular structures in groundbreaking detail. At the forefront of this field, high quality purified antibodies offer exceptional specificity, sensitivity, and reproducibility for use in a variety of applications, from basic research to clinical diagnostics. 

One of the primary benefits of using purified antibodies is their ability to enable customization. This feature allows for precise detailing of cellular neighborhoods, which is crucial for studying complex biological systems. Carrier-free purified antibodies allow you to customize your assay with the conjugate of your choice. This is particularly vital for achieving clear imaging results, without background proteins to reduce background noise. The improved sensitivity of carrier-free antibodies facilitates more accurate detection of targets, ensuring consistency and reproducibility across all tissues.

Additionally, purified antibodies enable multiplexing, which allows for the visualization of multiple targets within cellular microenvironments. This capability enhances the depth and breadth of your analyses, providing a comprehensive understanding of the functional relationships between cells and molecules within the tissue. Such insights lead to more targeted and personalized approaches to diagnostics, ultimately improving patient outcomes.

Top Carrier-free Antibodies

Our BSA free, glycerol-free, and azide-free antibodies are formulated at 1 mg/ml PBS and ready for conjugation.

Partnering with Us 

We understand that not all antibodies are created equal.  The Cell Marque™ purified antibody portfolio is carrier-free, ready-to-conjugate (ROC) and formulated to enhance flexibility in diagnostic and research workflows, making them ideal for spatial biology applications such as:

• Immunofluorescence
• MIBI (Multiplex Ion Beam Imaging)
• Oligonucleotide labeling
• Metal labeling for CyTOF® mass cytometry
• Imaging Mass Cytometry™ (IMC)
• Novel Modalities

Recent Publications Using Cell Marque™ Purified Antibodies

Dive into spatial biology studies where Cell Marque™ antibodies are being used: 

• Imaging Mass Spectrometry is an Accurate Tool in Differentiating Clear Cell Renal Cell Carcinoma and Chromophobe Renal Cell Carcinoma: A Proof-of-concept Study
• Assessing A Hyperspectral Image Analysis System To Study Tumor And Immune Cell Spatial Organizations Within Lung Tumor Microenvironments
• Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma
• Altered Spatial Composition of the Immune Cell Repertoire in Association to CD34⁺ Blasts in Myelodysplastic Syndromes and Secondary Acute Myeloid Leukemia
• Multiplexed digital spatial profiling of invasive breast tumors from Black and White women
• Spatial Tissue Proteomics Quantifies Inter- and Intratumor Heterogeneity in Hepatocellular Carcinoma (HCC)*
• Mural nodules in mucinous ovarian tumors represent a morphologic spectrum of clonal neoplasms: a morphologic, immunohistochemical, and molecular analysis of 13 cases
• Intra-Tumoral CD8+ T-Cell Infiltration and PD-L1 Positivity in Homologous Recombination Deficient Pancreatic Ductal Adenocarcinomav
• Spatial Distribution of Immune Cells in Head and Neck Squamous Cell Carcinomasv
• Characterization and digital spatial deconvolution of the immune microenvironment of intraductal oncocytic papillary neoplasms (IOPN) of the pancreas

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