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Intensify your seed train

Solutions to increase cell density and improve process efficiency in your upstream bioprocess.

Seed Train Platform

Future-proof your manufacturing with tailored solutions for seed train intensification

Seed train intensification allows for significantly higher cell densities compared to traditional batch processes. This is achieved through methods such as using perfusion processes, or integrating cryopreservation techniques to streamline the inoculation of production bioreactors.

  • Cellicon® Cell Retention Solution separates and retains cells in a culture while allowing the surrounding media and waste products to pass through, maintaining high cell densities, improving cell viability, and facilitating continuous production.
  • Mobius® High Cell Density Cryopreservation Assemblies enable seed train inoculation of cells at higher densities, ( > 50 x 106 cells/mL) and larger volumes and allows for direct inoculation of bioreactors.

Try it yourself! By submitting this webform, you will receive a free sample of the HCDC Bag Assembly (-80 °C) 100 mL or 250 mL, or HCDC Bag Assembly (-196 °C) 100 mL or 250 mL.  Take the opportunity to also request a demo of the Cellicon® Cell Retention Solution.


Cellicon® Cell Retention Solution: High Throughput and Reproducible Performance

Cellicon® Cell Retention Solution family for predictable linear scalability from lab to manufacturing scale.

The Cellicon® Cell Retention Solution includes a lab-scale flat sheet filter assembly and controller for perfused seed trains, featuring an intuitive piping and instrumentation diagram (P&ID) for process visualization. The process-scale version, with Mobius® Cell Retention System and Bio4C ACE™ software, offers scalable sizes (50–2000 L) ensuring easy integration with bioreactors. They offer:

  • High throughput and low fouling
  • Low crossflow and cell shear
  • Predictable linear scalability from lab to manufacturing scale
  • Reliable and reproducible performance
  • Comprehensive monitoring and precise control

They are easy to use, install and are ready to process in minutes.

 


Mobius® High Cell Density Cryopreservation Assemblies: Lower Risk of Contamination and Improved Reproducibility

Cellicon® Cell Retention Solution family for predictable linear scalability from lab to manufacturing scale.

These assemblies are specifically designed to facilitate the freeze and thaw of cryopreserved cells in either ultra-low temperature (-80 °C format) or liquid nitrogen (-196 °C format) freezers. Both formats are available in two assembly bag sizes of 100 mL and 250 mL in a 5-bag manifold. This multi-bag design:

  • Significantly reduces environmental contamination risk compared to vials or single bag operations
  • Improves process reproducibility by providing uniform inoculation feed across multiple campaigns

Discover more on the Seed Train Platform and how to intensify your upstream process.

 

 


Related Resources


REQUEST A SAMPLE/DEMO

By submitting this webform, you will receive a free sample of an HCDC Bag Assembly (1 assembly), or a demo of the Cellicon® Cell Retention Solution.

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