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Buchwald Group – Professor Product Portal

Stephen Buchwald

Professor Stephen Buchwald

The Buchwald group has developed a series of highly active and versatile palladium precatalysts and biarylphosphine ligands used in cross-coupling reactions for the formation of C-C, C–N, C–O, C–F, C–CF3, and C–S bonds. The ligands are electron-rich, and highly tunable to provide catalyst systems with a diverse scope, high stability and reactivity. Furthermore, the new series of precatalysts are air-, moisture and thermally-stable and display good solubility in common organic solvents. The use of precatalysts ensures the efficient generation of the active catalytic species and allows one to accurately adjust the ligand:palladium ratio. The ligands, precatalysts and methodology developed in the Buchwald group are user friendly and have rendered previously difficult cross couplings reactions, much easier to achieve.

Buchwald Group Website

Recent papers from the Buchwald Group

Lee HG, Milner PJ, Buchwald SL. 2014. Pd-Catalyzed Nucleophilic Fluorination of Aryl Bromides. J. Am. Chem. Soc.. 136(10):3792-3795.
Su M, Hoshiya N, Buchwald SL. 2014. Palladium-Catalyzed Amination of Unprotected Five-Membered Heterocyclic Bromides. Org. Lett.. 16(3):832-835.
Surry DS, Buchwald SL. Dialkylbiaryl phosphines in Pd-catalyzed amination: a user's guide. Chem. Sci.. 2(1):27-50.
Products available from the Buchwald Group
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