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Professor Laszlo Kurti

Professor Laszlo Kürti

Amines and their derivatives are ubiquitous substances since they make up the overwhelming majority of drug molecules, agrochemicals as well as many compounds that are produced by plants and living organisms (i.e., natural products). Aromatic amines appear as substructures in more than one third of drug candidates while aziridines, in which the nitrogen atom is bridged between two carbon atoms, are high-reactive and versatile building blocks for a large variety of functionalized amines. Not surprisingly, organic chemists spend a considerable amount of their time with the synthesis and late-stage functionalization of amines that serve as key chemical building blocks for the preparation of biologically active compounds, especially in medicinal chemistry. There is an urgent need for the development of novel carbon-nitrogen bond-forming methods and reagents that expand the toolbox of synthetic organic chemists and enable the environmentally friendly construction of complex molecular structures using the fewest number of chemical steps and generating the least amount waste. A highly attractive, but currently underdeveloped, approach is the utilization of weak bonds as a driving force to achieve the rapid formation of much stronger bonds under mild conditions.

The Kürti lab has been exploring several fundamentally new strategies for the transition-metal-free direct: (i) primary amination of arylmetals such as aryl Grignard reagents and arylboronic acids; (ii) intramolecular C(sp2)-H amination of arenes; (iii) double arylation of a suitable nitrogen linchpin reagents to afford N,N-diarylamines. We have also discovered, in collaboration with the Falck (UTSW) and Ess labs (BYU), the Rh-catalyzed direct N-H/N-alkyl aziridination of olefins as well as the primary (-NH2) and NH-alkyl amination of arenes, transformations that eluded synthetic chemists for decades. In-depth experimental and computational studies have already identified the critical factors required for efficient olefin NH- and N-alkyl aziridination as well as direct arene primary amination and led to the development of practical and chemoselective aminating agents.

Kürti Group Website

Recent papers from the Kürti Group

Jat JL, Paudyal MP, Gao H, Xu Q, Yousufuddin M, Devarajan D, Ess DH, Kürti L, Falck JR. 2014. Direct Stereospecific Synthesis of Unprotected N-H and N-Me Aziridines from Olefins. Science. 343(6166):61-65.
Gao H, Zhou Z, Kwon D, Coombs J, Jones S, Behnke NE, Ess DH, Kürti L. 2017. Rapid heteroatom transfer to arylmetals utilizing multifunctional reagent scaffolds. Nature Chem. 9(7):681-688.
Kattamuri PV, Yin J, Siriwongsup S, Kwon D, Ess DH, Li Q, Li G, Yousufuddin M, Richardson PF, Sutton SC, et al. 2017. Practical Singly and Doubly Electrophilic Aminating Agents: A New, More Sustainable Platform for Carbon?Nitrogen Bond Formation. J. Am. Chem. Soc.. 139(32):11184-11196.


  • Organic Synthetic Chemistry

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