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Raines Group – Professor Product Portal

Professor Ronald Raines

Professor Ron Raines works on the development of reagents and tools for chemical biology, such as the traceless Staudinger ligation reagent (670359). DTBA (774405), a superior biological reducing reagent to DTT, is another technology to come out of the Raines Lab. Other exciting research has led to an RNA-cleaving enzyme that is in a multi-site human clinical trial as an anti-cancer agent, revealed that an unappreciated force—the n-to-pi* interaction—stabilizes all proteins, created hyperstable and human-scale synthetic collagens, and established chemical processes to synthesize proteins and convert crude biomass into useful fuels and chemicals.

Raines Group Website

Recent papers from the Raines Group

Lukesh JC, Palte MJ, Raines RT. 2012. A Potent, Versatile Disulfide-Reducing Agent from Aspartic Acid. J. Am. Chem. Soc.. 134(9):4057-4059.
Levine MN, Raines RT. 2012. Trimethyl lock: a trigger for molecular release in chemistry, biology, and pharmacology. Chem. Sci.. 3(8):2412.
Tam A, Raines RT. 2009. Chapter 2 Protein Engineering with the Traceless Staudinger Ligation.25-44.
Products available at Aldrich from the Raines Laboratory


  • Organic Synthetic Chemistry
  • Chemical Biology

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