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Wulff Group – Professor Product Portal

Professor William Wulff

Professor William Wulff

The research areas of interest to the Wulff group include enantioselective catalysis, mechanisms of asymmetric catalysis, macromolecular chemistry, Fischer carbene complexes in organic synthesis and the total synthesis of natural products. Vaulted biaryl ligands VANOL and VAPOL developed by the Wulff group as topographical alternatives to BINOL have been demonstrated to be effective in a variety of useful catalytic asymmetric reactions. Noteworthy among these are asymmetric aziridinations and aminoallylations. Finally, hydrogen phosphate derivatives of these ligands have found a number of applications, largely developed by Jon Antilla.

Wulff Group Website

Recent papers from the Wulff Group

Zhou Y, Gupta AK, Mukherjee M, Zheng L, Wulff WD. 2017. Multicomponent Catalytic Asymmetric Synthesis of trans-Aziridines. J. Org. Chem.. 82(24):13121-13140.
Ren H, Wulff WD. 2011. Direct Catalytic Asymmetric Aminoallylation of Aldehydes: Synergism of Chiral and Nonchiral Brønsted Acids. J. Am. Chem. Soc.. 133(15):5656-5659.
Wang H, Predeus AV, Wulff WD. 2013. Synthesis of [m.n]Cyclophanes: Regiochemistry Transfer from Vinyl Halides to Cyclophanes via Fischer Carbene Complexes. Chem. Eur. J.. 19(25):8261-8267.


  • Organic Synthetic Chemistry
  • Catalysis

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