Transition metal catalyzed cross-coupling reactions are one of the most important and widely used reactions in modern organic synthesis. In this presentation, you will learn about a newly developed class of phosphine ligands targeting a relatively underexplored type of cross-coupling reaction.
MPhos is a novel class of ferrocene-based unsymmetrical ligands. Along with their corresponding PdCl2 pre-catalysts, these ligands are employed for a variety of Csp2-Csp3 couplings reactions such as Murahashi-Feringa, Kumada-Corriu, Negishi and Suzuki-Miyaura. Various substrates include “drug-like” molecules to demonstrate its potential applications in API synthesis. The details of the study will be discussed in the presentation.
In this webinar, you will learn:
- Difficulties in Csp2-Csp3 Couplings
- Benefits of MPhos ligands and precatalysts
Speaker
Thomas Colacot, PhD
Merck
R&D Fellow and Director of Global Technology Innovation, Life Science Business
Thomas J. Colacot holds a Ph.D. in chemistry and an MBA. He joined Merck in 2018 and currently serves as an R&D Fellow and Director of Global Technology Innovation in the Life Science Business division. He is an expert in organometallics and homogeneous catalysis and has a strong track record of commercializing innovative products. Colacot has published over 120 peer-reviewed articles and holds 67 international patents. He has been recognized with various awards, including a lifetime achievement award from the Chairman and CEO of Merck KGaA, Darmstadt, Germany. From 1995 to 2018, he was instrumental in establishing a successful homogeneous catalysis program at Johnson Matthey.
Chemistry and synthesis
- Chemistry and synthesis
Duration:1h
Language:English
Session 1:presented July 18, 2023
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