CN
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
Synonyms:
ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
Species:
Human ABCB1 (5243), dog ABCB1 (403879), domestic cat ABCB1 (493707), Thale Cress ABCB1 (818265), naked mole-rat Abcb1 (101702843), domestic guinea pig Abcb1 (100733532), Domestic Rabbit ABCB1 (100008914), sheep ABCB1 (443367), Horse ABCB1 (100034074), cow ABCB1 (281585)
UniProtKB ID:
Gene ID:
- Human(5243) Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
- dog(403879) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- domestic cat(493707) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Thale Cress(818265) ABC transporter B family member 1
- naked mole-rat(101702843) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- domestic guinea pig(100733532) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Domestic Rabbit(100008914) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- sheep(443367) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Horse(100034074) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- cow(281585) ATP-binding cassette, sub-family B (MDR/TAP), member 1
Custom & Knockdown Gene Products
siRNA
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Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Small Molecule - Agonist
Product Number
Description
Species
Small Molecule - Antagonist
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-CD243-APC antibody produced in mouse, clone UIC2,
Species Reactivity
Application
flow cytometry
Monoclonal Anti-CD243 antibody produced in mouse, clone UIC2,
Species Reactivity
human
Application
flow cytometry
Anti-ABCB1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, canine, guinea pig, horse, human, mouse, pig, rabbit, sheep, zebrafish
Application
immunohistochemistry
western blot
western blot
Anti-ABCB1 antibody produced in rabbit biotin conjugated, affinity isolated antibody,
Species Reactivity
bovine, canine, guinea pig, horse, human, mouse, pig, rabbit, sheep, zebrafish
Application
immunohistochemistry
Anti-MDR1 Antibody, extracellular human specific Pgp, clone MC57, clone MC57, Chemicon®, from mouse,
Species Reactivity
human
Application
flow cytometry
immunohistochemistry
immunohistochemistry
Cell Lines
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Description
Species
Kits
Product Number
Description
Species
Small Molecule - Mixed Agonist/Antagonist
Proteins
Product Number
Description
Species
SB-MDR1-Hi5-PREDEASY-ATPase kit, membrane based kit for Human MDR1 ATPase Transport Assays,
Species
human
esiRNA
Product Number
Description
Species