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I8898

Sigma-Aldrich

Ivermectin

Synonym(s):

22,23-Dihydroavermectin B1, MK-933

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100 μL
CN¥6,192.34

CN¥6,192.34

Estimated to ship onJuly 11, 2025Details

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100 μL
CN¥6,192.34

About This Item

CAS Number:
70288-86-7
MDL number:
MFCD00869511
UNSPSC Code:
12352200
PubChem Substance ID:
24278497
NACRES:
NA.77

CN¥6,192.34

Estimated to ship onJuly 11, 2025Details

A recombinant, preservative-free antibody is available for your target. Try ZRB1606
Request a Bulk Order

form

powder

Quality Level

100

solubility

MEK: 50 mg/mL

antibiotic activity spectrum

parasites

application(s)

agriculture
environmental

Mode of action

cell membrane | interferes

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

storage temp.

2-8°C

SMILES string

[H][C@@]1(O[C@]2(CC[C@@H]1C)C[C@@H]3C[C@@H](C\C=C(C)\[C@@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)\C=C\C=C6/CO[C@]7([H])[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]67O)O2)[C@@H](C)CC

InChI

1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1

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Show Differences

1 of 4

This Item
D1260674508673110
（11-巯基十一烷基）-,,-三甲基溴化铵

733385

（11-巯基十一烷基）-,,-三甲基溴化铵

十烃溴铵 crystalline

D1260

十烃溴铵

(11-巯基十一烷基)四(乙二醇) 90%

674508

(11-巯基十一烷基)四(乙二醇)

三乙二醇单-11-巯基十一烷基醚 95%

673110

三乙二醇单-11-巯基十一烷基醚

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

mp

113-118 °C

mp

263-267 °C (lit.)

mp

-

mp

-

form

solid

form

crystalline

form

-

form

-

storage temp.

−20°C

storage temp.

-

storage temp.

−20°C

storage temp.

−20°C

General description

Ivermectin is a macro-cyclic lactone,[1] derived from avermectin.[2] It functions as an antiparasitic agent. Ivermectin is used against gastrointestinal roundworms, lungworms, mites and lice. It is used to treat onchocerciasis, strongyloidiasis, ascariasis and filariases.[2]

Application

Ivermectin has been used:
  • in Caenorhabditis elegans fecundity assay[3]
  • in larval development test[4]
  • to measure in vivo topical acaricide activity of compounds in rats[5]
  • to assess its acute and chronic effects to zebrafish[6]
  • in percutaneous drug injection method to treat cystic echinococcosis[7]
  • in liquid chromatography with fluorescence detection method[8]

Biochem/physiol Actions

Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor; also modulates glutamate-GABA-activated chloride channels.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

Primarily ivermectin B1a.

Signal Word

Danger

Hazard Statements

H300,H311,H351,H360D,H410

Hazard Classifications

Acute Tox. 1 Oral - Acute Tox. 3 Dermal - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Repr. 1B

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Certificates of Analysis (COA)

    Lot/Batch Number
    MKCX8161
    MKCV0451
    MKCM8215
    MKCM4277
    MKCK0618

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