APITD1
apoptosis-inducing, TAF9-like domain 1
Synonyms:
CENP-S, CENPS, FAAP16, MHF1
Species:
Human APITD1 (378708), Mouse Apitd1 (69928), Rat Apitd1 (100534597), chicken APITD1 (771417), sheep APITD1 (101114968), Domestic Rabbit APITD1 (100534620), cow APITD1 (613732), domestic cat APITD1 (101096495), dog APITD1 (487450), Zebrafish apitd1 (569270)
UniProtKB ID:
Gene ID:
- Human(378708) Summary: This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (nucleosome distal) complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream cortistatin (CORT) gene, as represented in GeneID:100526739. An APITD1-related pseudogene has been identified on chromosome 7. [provided by RefSeq, Nov 2010]
- Mouse(69928) apoptosis-inducing, TAF9-like domain 1
- Rat(100534597) apoptosis-inducing, TAF9-like domain 1
- chicken(771417) apoptosis-inducing, TAF9-like domain 1
- sheep(101114968) apoptosis-inducing, TAF9-like domain 1
- Domestic Rabbit(100534620) apoptosis-inducing, TAF9-like domain 1
- cow(613732) apoptosis-inducing, TAF9-like domain 1
- domestic cat(101096495) apoptosis-inducing, TAF9-like domain 1
- dog(487450) apoptosis-inducing, TAF9-like domain 1
- Zebrafish(569270) apoptosis-inducing, TAF9-like domain 1
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