ATP6V0E1
ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
Synonyms:
ATP6H, ATP6V0E, M9.2, Vma21, Vma21p
Species:
Human ATP6V0E1 (8992), Rat Atp6v0e1 (94170), naked mole-rat Atp6v0e1 (101726308), chicken ATP6V0E1 (768854), dog ATP6V0E1 (403729), cow ATP6V0E1 (338075), domestic cat ATP6V0E1 (101091676), sheep ATP6V0E1 (101108422), domestic guinea pig Atp6v0e1 (100726215)
UniProtKB ID:
Gene ID:
- Human(8992) Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is possibly part of the V0 subunit. Since two nontranscribed pseudogenes have been found in dog, it is possible that the localization to chromosome 2 for this gene by radiation hybrid mapping is representing a pseudogene. Genomic mapping puts the chromosomal location on 5q35.3. [provided by RefSeq, Jul 2008]
- Rat(94170) ATPase, H+ transporting, lysosomal, V0 subunit e1
- naked mole-rat(101726308) ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
- chicken(768854) ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
- dog(403729) ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
- cow(338075) ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
- domestic cat(101091676) ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
- sheep(101108422) ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
- domestic guinea pig(100726215) ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
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