CHRNA7
cholinergic receptor, nicotinic, alpha 7 (neuronal)
Synonyms:
CHRNA7-2, NACHRA7
Species:
Human CHRNA7 (1139), Mouse Chrna7 (11441), Rat Chrna7 (25302), domestic cat CHRNA7 (751113), Zebrafish chrna7 (394199), dog CHRNA7 (488696), cow CHRNA7 (282178), Horse CHRNA7 (100060521), chicken CHRNA7 (374001), naked mole-rat Chrna7 (101720562)
UniProtKB ID:
Gene ID:
- Human(1139) Summary: The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
- Mouse(11441) cholinergic receptor, nicotinic, alpha polypeptide 7
- Rat(25302) cholinergic receptor, nicotinic, alpha 7 (neuronal)
- domestic cat(751113) cholinergic receptor, nicotinic, alpha 7 (neuronal)
- Zebrafish(394199) cholinergic receptor, nicotinic, alpha polypeptide 7
- dog(488696) cholinergic receptor, nicotinic, alpha 7 (neuronal)
- cow(282178) cholinergic receptor, nicotinic, alpha 7
- Horse(100060521) cholinergic receptor, nicotinic, alpha 7 (neuronal)
- chicken(374001) cholinergic receptor, nicotinic, alpha 7 (neuronal)
- naked mole-rat(101720562) cholinergic receptor, nicotinic, alpha 7 (neuronal)
- domestic guinea pig(100720640) cholinergic receptor, nicotinic, alpha 7 (neuronal)
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Small Molecule - Agonist
Product Number
Description
Species
(−)-Nicotine solution, 1.0 mg/mL, analytical standard, for drug analysis,
Species
human, mouse, rat
Small Molecule - Antagonist
Product Number
Description
Species
(−)-Nicotine solution, 1.0 mg/mL, analytical standard, for drug analysis,
Species
human, mouse, rat
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-CHRNA7, IgG fraction of antiserum,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-CHRNA7 (AB1) antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
bovine, guinea pig, horse, human, rabbit
Application
western blot
Anti-Nicotinic Acetylcholine Receptor α7 Antibody, Chemicon®, from rabbit,
Species Reactivity
human, mouse, rat
Application
western blot
Small Molecule - Blocker
esiRNA
Product Number
Description
Species