CLCN3
chloride channel, voltage-sensitive 3
Synonyms:
CLC3, ClC-3
Species:
Human CLCN3 (1182), Mouse Clcn3 (12725), Rat Clcn3 (84360), Horse CLCN3 (100061225), domestic cat CLCN3 (101092513), naked mole-rat Clcn3 (101704112), dog CLCN3 (477354), Domestic Rabbit CLCN3 (100008673), chicken CLCN3 (422432), Zebrafish clcn3 (559340) ...More
UniProtKB ID:
Gene ID:
- Human(1182) Summary: This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
- Mouse(12725) chloride channel 3
- Rat(84360) chloride channel, voltage-sensitive 3
- Horse(100061225) chloride channel, voltage-sensitive 3
- domestic cat(101092513) chloride channel, voltage-sensitive 3
- naked mole-rat(101704112) chloride channel, voltage-sensitive 3
- dog(477354) chloride channel, voltage-sensitive 3
- Domestic Rabbit(100008673) chloride channel, voltage-sensitive 3
- chicken(422432) chloride channel, voltage-sensitive 3
- Zebrafish(559340) chloride channel 3
- sheep(101114498) chloride channel, voltage-sensitive 3
- cow(522719) chloride channel 3
- domestic guinea pig(100135501) chloride channel 3
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-Clcn3 - Percp antibody produced in mouse, clone S258-5, purified immunoglobulin,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-Clcn3 - Atto 488 antibody produced in mouse, clone S258-5, purified immunoglobulin,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-Clcn3 - Atto 390 antibody produced in mouse, clone S258-5, purified immunoglobulin,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-Clcn3 - Rpe antibody produced in mouse, clone S258-5, purified immunoglobulin,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-CLCN3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot