Merck
CN

CYP1A2

cytochrome P450, family 1, subfamily A, polypeptide 2

Synonyms:
CP12, P3-450, P450(PA)
Species:
Human CYP1A2 (1544), Mouse Cyp1a2 (13077), Rat Cyp1a2 (24297), domestic guinea pig Cyp1a2 (100135513), domestic cat CYP1A2 (554345), chicken CYP1A2 (414856), cow CYP1A2 (503552), dog CYP1A2 (494010)
UniProtKB ID:
P05177, Q16754, Q6NWU5, Q9BXX7, Q9UK49
Gene ID:
  • Human(1544) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008]
  • Mouse(13077) cytochrome P450, family 1, subfamily a, polypeptide 2
  • Rat(24297) cytochrome P450, family 1, subfamily a, polypeptide 2
  • domestic guinea pig(100135513) cytochrome P450, family 1, subfamily a, polypeptide 2
  • domestic cat(554345) cytochrome P450 1A2
  • chicken(414856) cytochrome P450, family 1, subfamily A, polypeptide 2
  • cow(503552) cytochrome P450, family 1, subfamily A, polypeptide 2
  • dog(494010) cytochrome P450, family 1, subfamily A, polypeptide 2

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB1408927
Anti-CYP1A2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
SAB1401102
Anti-CYP1A2 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
AB1248
Anti-Cytochrome P450 Enzyme CYP1A2 Antibody, serum, Chemicon®,
Species Reactivity
human
Application
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
N5893
(±)-Naringenin, ≥95%,
Species
human
E3768
(−)-Epigallocatechin, ≥95% (HPLC), from green tea,
Species
human
N1000
1-Naphthol, ReagentPlus®, ≥99%,
Species
human
N2780
1-Naphthol, BioXtra, ≥99%,
Species
human
P7903
Pipemidic acid, ,
Species
human

Proteins

Product Number
Description
Species
MTOXCE1A2
CypExpress™ 1A2 Cytochrome P450 human, ,
Species
human
C5614
Cytochrome P450 human, 1A2 Isozyme Microsomes, with P450 Reductase and cytochrome b5, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4),
Species
human

esiRNA

Product Number
Description
Species
EHU001461
MISSION® esiRNA, targeting human CYP1A2,
Species
human