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SAB1401102

Sigma-Aldrich

Anti-CYP1A2 antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

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Synonym(s):
CP12, P3-450, P450(PA)
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

western blot: 1 μg/mL

NCBI accession no.

BC067427.1

UniProt accession no.

P05177

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CYP1A2(1544)

General description

Cytochrome P450 family 1 subfamily A member 2 (CYP1A2) is one of the P450 isoforms of the CYP1 family. It is encoded by the gene mapped to human chromosome 15q24.1 and is specifically expressed in the liver.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme′s endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3′ untranslated region. (provided by RefSeq)

Immunogen

CYP1A2 (AAH67427.1, 1 a.a. ~ 516 a.a) full-length human protein.

Sequence
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIDSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN

Biochem/physiol Actions

Cytochrome P450 family 1 subfamily A member 2 (CYP1A2) plays a vital role in oxidative metabolism of various drugs, such as clozapine, imipramine, caffeine, paracetamol, phenacetin, theophylline, tacrine and some neurotoxins. In addition, it also activate procarcinogens, including aromatic heterocyclic amines and polycyclic aromatic hydrocarbons. Variation in the gene expression has been observed during inflammation.

Physical form

Solution in phosphate buffered saline, pH 7.4

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Pathway-targeted pharmacogenomics of CYP1A2 in human liver
Klein K, et al.
Frontiers in Pharmacology, 1, 129-129 (2010)
Six Novel Nonsynonymous CYP1A2 Gene Polymorphisms: Catalytic Activities of the Naturally Occurring Variant Enzymes
Murayama N, et al.
Journal of Pharmacology and Experimental Therapeutics, 308(1), 300-306 (2004)
Functional significance of a C?A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine
Sachse C, et al.
British Journal of Clinical Pharmacology, 47(4), 445-449 (1999)

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