DIO2
deiodinase, iodothyronine, type II
Synonyms:
5DII, D2, DIOII, SelY, TXDI2
Species:
Human DIO2 (1734), Mouse Dio2 (13371), Rat Dio2 (65162), Horse DIO2 (100052547), Zebrafish dio2 (352937), cow DIO2 (494548), Goat DIO2 (100861220), chicken DIO2 (373903), sheep DIO2 (100310793), domestic guinea pig Dio2 (100721073) ...More
UniProtKB ID:
Gene ID:
- Human(1734) Summary: The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- Mouse(13371) deiodinase, iodothyronine, type II
- Rat(65162) deiodinase, iodothyronine, type II
- Horse(100052547) deiodinase, iodothyronine, type II
- Zebrafish(352937) deiodinase, iodothyronine, type II
- cow(494548) deiodinase, iodothyronine, type II
- Goat(100861220) deiodinase, iodothyronine, type II
- chicken(373903) deiodinase, iodothyronine, type II
- sheep(100310793) deiodinase, iodothyronine, type II
- domestic guinea pig(100721073) deiodinase, iodothyronine, type II
- Domestic Rabbit(100354221) deiodinase, iodothyronine, type II
- dog(490813) deiodinase, iodothyronine, type II
- naked mole-rat(101697296) deiodinase, iodothyronine, type II
- domestic cat(101088170) deiodinase, iodothyronine, type II
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-DIO2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
esiRNA
Product Number
Description
Species