Merck
CN

ESR2

estrogen receptor 2 (ER beta)

Synonyms:
ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2
Species:
UniProtKB ID:
Gene ID:
  • Human(2100) Summary: This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
  • Mouse(13983) estrogen receptor 2 (beta)
  • Rat(25149) estrogen receptor 2 (ER beta)
  • dog(403639) estrogen receptor 2 (ER beta)
  • chicken(395575) estrogen receptor 2 (ER beta)
  • domestic guinea pig(100731304) estrogen receptor 2 (ER beta)
  • Domestic Rabbit(100346748) estrogen receptor 2 (ER beta)
  • domestic cat(101086317) estrogen receptor 2 (ER beta)
  • Horse(100033964) estrogen receptor 2 (ER beta)
  • cow(281146) estrogen receptor 2 (ER beta)
  • Goat(100860823) estrogen receptor 2 (ER beta)
  • sheep(443066) estrogen receptor 2 (ER beta)

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Small Molecule - Activator

Product Number
Description
Species
β-Nicotinamide adenine dinucleotide sodium salt, ,
Species
human
β-Nicotinamide adenine dinucleotide hydrate, ≥99%,
Species
human
β-Nicotinamide adenine dinucleotide, pkg of 10 mg (per vial),
Species
human
β-Nicotinamide adenine dinucleotide hydrate, ≥96.5% (HPLC), ≥96.5% (spectrophotometric assay), from yeast,
Species
human
β-Nicotinamide adenine dinucleotide, pkg of 50 mg (per vial),
Species
human

Small Molecule - Agonist

Product Number
Description
Species
ERB-041, ≥98% (HPLC),
Species
human

Small Molecule - Allosteric Modulator

Product Number
Description
Species
Estramustine sodium phosphate, ,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Fulvestrant, Vetec, reagent grade, >98%,
Species
human
4′-Hydroxy-4-biphenylcarbonitrile, 97%,
Species
human
4,4′-Dihydroxybiphenyl, 97%,
Species
human
Coumestrol, ≥95.0% (HPLC),
Species
mouse, human, rat
Coumestrol, BioReagent, suitable for fluorescence, ≥97.5% (HPLC),
Species
mouse, human, rat

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Estrogen Receptor β Antibody, clone 9.88, clone 9.88, from mouse,
Species Reactivity
human, mouse, rat
Application
immunoprecipitation (IP)
western blot
Anti-ESR2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, human, mouse, pig, rat
Application
western blot
Anti-Estrogen Receptor-β antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

western blot
Monoclonal Anti-ESR2 antibody produced in mouse, clone 3F3, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence

western blot
Anti-ESR2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
western blot

Cell Lines

Product Number
Description
Species
MCF10A CELLS ESR2 (-/-), ,
Species
human

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
β-Estradiol, ≥98%,
Species
human, mouse, rat
β-Estradiol, BioReagent, powder, suitable for cell culture,
Species
human, mouse, rat
Mifepristone, ≥98%,
Species
human, mouse, rat

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human ESR2,
Species
human