SAB4500814
Anti-Estrogen Receptor-β antibody produced in rabbit
affinity isolated antibody
Synonym(s):
ESR2, ESTRB, Estrogen receptor β, NR3A2
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 59 kDa
species reactivity
human, rat, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ESR2(2100)
General description
Estrogen Receptor-β (ERβ) is a member of the nuclear receptor superfamily. It has nine exons and is mapped to human chromosome 14q23.2.
Anti-Estrogen Receptor-β Antibody detects endogenous levels of total Estrogen Receptor-β protein.
Anti-Estrogen Receptor-β Antibody detects endogenous levels of total Estrogen Receptor-β protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human Estrogen Receptor-beta.
Immunogen Range: 71-120
Immunogen Range: 71-120
Application
Anti-Estrogen Receptor-βantibody has been used in western blotting .{42,43}
Biochem/physiol Actions
Estrogen Receptor-β (ERβ) is involved in immune and inflammatory response. In females, estrogen receptor β (ESR2) is expected to play an important role in the progress of MDD (major depressive disorder). Aberrations in ESR2 gene result in bone mineral density variation.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Ratio of Circulating Estrogen Receptors Beta and Alpha (ER?/ER?) Indicates Endoscopic Activity in Patients with Crohn's Disease
Linares PM, et al.
Digestive Diseases and Sciences (2017)
Polymorphisms in the estrogen receptor beta (ESR2) gene are associated with bone mineral density in Caucasian men and women
Ichikawa S, et al.
The Journal of Clinical Endocrinology and Metabolism (2005)
Interaction of estrogen receptor ? and negative life events in susceptibility to major depressive disorder in a Chinese Han female population
Zhang J, et al.
Journal of Affective Disorders (2017)
Xinyan Wang et al.
Journal of molecular histology, 52(4), 741-749 (2021-05-29)
Accumulating evidence has suggests that women with advanced endometriosis exhibit alterations in the expression of genes in the endometrium compared to healthy controls. Furthermore, replication stress is a characteristic feature of cancer cells, which results from sustained proliferative signaling induced
Chun-E Ren et al.
International journal of molecular sciences, 16(3), 5864-5885 (2015-03-18)
Epithelial stromal cells represent a major cellular component of human uterine endometrium that is subject to tight hormonal regulation. Through cell-cell contacts and/or paracrine mechanisms, stromal cells play a significant role in the malignant transformation of epithelial cells. We isolated
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