IL4
interleukin 4
Synonyms:
BCGF-1, BCGF1, BSF-1, BSF1, IL-4
Species:
Human IL4 (3565), Mouse Il4 (16189), Rat Il4 (287287), Zebrafish il4 (100188894), chicken IL4 (416330), dog IL4 (403785), domestic cat IL4 (751514), Horse IL4 (100034225), cow IL4 (280824), Goat IL4 (100860814) ...More
UniProtKB ID:
Gene ID:
- Human(3565) Summary: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
- Mouse(16189) interleukin 4
- Rat(287287) interleukin 4
- Zebrafish(100188894) interleukin 4
- chicken(416330) interleukin 4
- dog(403785) interleukin 4
- domestic cat(751514) interleukin 4
- Horse(100034225) interleukin 4
- cow(280824) interleukin 4
- Goat(100860814) interleukin 4
- sheep(101122781) interleukin 4
- sheep(443327) interleukin 4
- Domestic Rabbit(100302454) interleukin 4
- naked mole-rat(101706414) interleukin 4
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