MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Synonyms:
CMM5, MSH-R, SHEP2
Species:
Human MC1R (4157), Mouse Mc1r (17199), Rat Mc1r (292083), domestic cat MC1R (493917), dog MC1R (489652), Horse MC1R (100136907), cow MC1R (281298), Goat MC1R (100750239), Domestic Rabbit MC1R (100340038), sheep MC1R (102099064) ...More
UniProtKB ID:
Gene ID:
- Human(4157) Summary: This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008]
- Mouse(17199) melanocortin 1 receptor
- Rat(292083) melanocortin 1 receptor
- domestic cat(493917) melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
- dog(489652) melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
- Horse(100136907) melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
- cow(281298) melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
- Goat(100750239) melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
- Domestic Rabbit(100340038) melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
- sheep(102099064) melanocortin 1 receptor
- naked mole-rat(101726602) melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
- chicken(427562) melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
- Zebrafish(353151) melanocortin 1 receptor
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti Melanocortin 1 Receptor Antibody, clone 24GB640, Rabbit Monoclonal, clone 24GB640, recombinant rabbit monoclonal, expressed in HEK293 cells,
Species Reactivity
human, rat
Application
flow cytometry
immunofluorescence
western blot
immunofluorescence
western blot
Anti-MC1R (C-terminal) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
western blot
Anti- MC1 Receptor antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-Melanocortin Receptor-1 Antibody, Chemicon®, from rabbit,
Species Reactivity
mouse
Application
ELISA
western blot
western blot