PABPN1
poly(A) binding protein, nuclear 1
Synonyms:
OPMD, PAB2, PABII, PABP-2, PABP2
Species:
Human PABPN1 (8106), Mouse Pabpn1 (54196), Rat Pabpn1 (116697), domestic guinea pig Pabpn1 (100728725), dog PABPN1 (100170671), naked mole-rat Pabpn1 (101714601), Zebrafish pabpn1 (406543), cow PABPN1 (282298), chicken PABPN1 (769028)
UniProtKB ID:
Gene ID:
- Human(8106) Summary: This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. [provided by RefSeq, Dec 2010]
- Mouse(54196) poly(A) binding protein, nuclear 1
- Rat(116697) poly(A) binding protein, nuclear 1
- domestic guinea pig(100728725) poly(A) binding protein, nuclear 1
- dog(100170671) poly(A) binding protein, nuclear 1
- naked mole-rat(101714601) poly(A) binding protein, nuclear 1
- Zebrafish(406543) poly(A) binding protein, nuclear 1
- cow(282298) poly(A) binding protein, nuclear 1
- chicken(769028) poly(A) binding protein, nuclear 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PABPN1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
western blot
KD-Validated Anti Poly(A) Binding Protein Nuclear 1 Antibody, clone 24GB365, Rabbit Monoclonal, clone 24GB365, recombinant rabbit monoclonal, expressed in HEK293 cells,
Species Reactivity
human, rat
Application
flow cytometry
immunofluorescence
western blot
immunofluorescence
western blot
Anti-PABPN1 antibody produced in rabbit, ,
Species Reactivity
human, mouse
Application
western blot
Anti-PN1 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-PABP-2 Antibody, serum, from rabbit,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
esiRNA
Product Number
Description
Species