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PRKCH

protein kinase C, eta

Synonyms:
PKC-L, PKCL, PRKCL, nPKC-eta
Species:
UniProtKB ID:
Gene ID:
  • Human(5583) Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. [provided by RefSeq, Jul 2008]
  • Mouse(18755) protein kinase C, eta
  • Rat(81749) protein kinase C, eta
  • Horse(100051560) protein kinase C, eta
  • domestic guinea pig(100736222) protein kinase C, eta
  • domestic cat(101082413) protein kinase C, eta
  • dog(490722) protein kinase C, eta
  • Domestic Rabbit(100344184) protein kinase C, eta
  • sheep(101105574) protein kinase C, eta
  • cow(518542) protein kinase C, eta
  • chicken(423518) protein kinase C, eta
  • naked mole-rat(101716769) protein kinase C, eta

Custom & Knockdown Gene Products

Small Molecule - Agonist

Product Number
Description
Species
Oleic acid, ≥99% (GC),
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti Protein Kinase C Eta Antibody, clone 24GB1480, Rabbit Monoclonal, clone 24GB1480, recombinant rabbit monoclonal, expressed in HEK293 cells,
Species Reactivity
human
Application
flow cytometry
immunofluorescence

western blot
Anti-PRKCH antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
Anti-PRKCH antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-phospho-PKCη (Thr655) Antibody, Upstate®, from rabbit,
Species Reactivity
human
Application
western blot
Anti-PRKCH antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

Small Molecule - Inhibitor

Product Number
Description
Species
Xanthone, 97%,
Species
mouse
H-7 dihydrochloride, ≥98% (HPLC),
Species
human
Oleic acid, ≥99% (GC),
Species
human
GSK690693, ≥98% (HPLC),
Species
human

Proteins

Product Number
Description
Species
PKCη, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
PKC η Protein, active, 10 µg, Active, N-terminal His6-tagged, recombinant amino acids 2-end, of human PKC eta. For use in Kinase Assays.,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Prkch,
Species
mouse
MISSION® esiRNA, targeting human PRKCH,
Species
human