PSMC4
proteasome (prosome, macropain) 26S subunit, ATPase, 4
Synonyms:
MIP224, RPT3, S6, TBP-7, TBP7
Species:
Human PSMC4 (5704), Mouse Psmc4 (23996), Rat Psmc4 (117262), Zebrafish psmc4 (326884), domestic guinea pig Psmc4 (100727625), naked mole-rat Psmc4 (101717896), sheep PSMC4 (101117608), Domestic Rabbit PSMC4 (100341658), cow PSMC4 (510029), Horse PSMC4 (100064604) ...More
UniProtKB ID:
Gene ID:
- Human(5704) Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
- Mouse(23996) proteasome (prosome, macropain) 26S subunit, ATPase, 4
- Rat(117262) proteasome (prosome, macropain) 26S subunit, ATPase, 4
- Zebrafish(326884) proteasome (prosome, macropain) 26S subunit, ATPase, 4
- domestic guinea pig(100727625) proteasome (prosome, macropain) 26S subunit, ATPase, 4
- naked mole-rat(101717896) proteasome (prosome, macropain) 26S subunit, ATPase, 4
- sheep(101117608) proteasome (prosome, macropain) 26S subunit, ATPase, 4
- Domestic Rabbit(100341658) proteasome (prosome, macropain) 26S subunit, ATPase, 4
- cow(510029) proteasome (prosome, macropain) 26S subunit, ATPase, 4
- Horse(100064604) proteasome (prosome, macropain) 26S subunit, ATPase, 4
- domestic cat(101090224) proteasome (prosome, macropain) 26S subunit, ATPase, 4
- dog(476459) proteasome (prosome, macropain) 26S subunit, ATPase, 4
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti PSMC4 Antibody, clone 24GB1400, Rabbit Monoclonal, clone 24GB1400, recombinant rabbit monoclonal, expressed in HEK293 cells,
Species Reactivity
human, rat
Application
flow cytometry
immunofluorescence
western blot
immunofluorescence
western blot
Anti-PSMC4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-PSMC4 antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
esiRNA
Product Number
Description
Species