Monoclonal antibody drug discovery begins with identifying the functional therapeutic target and evaluating its role in the disease of interest. This identification is then followed by characterization of the molecular mechanisms addressed by this target. All targets should be druggable and modulated by the potential therapeutic. These early phases have been simplified by the advent of various genome engineering and hybridoma techniques, which can be used for biotherapeutic antibody target and lead discovery.
Get Ahead of the Game
Uncover, select, and validate new targets with a strong link to disease. Choices made early in the drug discovery process are highly linked to ultimate failure or success in a drug discovery program. Identification of the most suitable, druggable target is key to success. We offer a complete set of curated genome-wide, pathway-specific, and protein family targeting screening tools to facilitate your target discovery.
• Functional Genomics Screening Tools for Target Identification
• In vitro Tools for Target Validation
• mAb Production
• Purification
• Screening and Selecting mAb Candidates
• Lead Optimization
• Preclinical Models
• PK/PD and Immunogenicity
Related Resources
- Pooled CRISPR Screening
CRISPR lentiviral products are powerful research tools for the discovery of novel targets essential to human health and disease. As a world leader in the production of lentiviral libraries, we design and build custom pools to any specifications.
- MULTI-seq Sample Multiplexing for Single Cell Analysis
scRNA-seq is a powerful tool to analyze gene expression at the single-cell level. MULTI-seq was developed to multiplex sample types, allowing for multiple samples to be pooled together in the same single-cell analysis workflow.
- The ELISpot Assay Enables Functional Analysis of Cellular Immunology
Recent improvements to the design of multiwell microplates, including use of membranes with reduced background fluorescence, have bolstered the widespread application of ELISpot assays.
- Designing Peptides
When selecting peptides for custom synthesis, several important factors should be considered during the design process. These considerations include sequence length, solubility and sequence stability.
- Protein Expression Systems
An overview of bacterial, yeast, insect, and mammalian protein expression systems and their various advantages and disadvantages.
- Primary Cell Culture Basics
A comprehensive overview of animal and human primary cell lines and media and how they are used in cell culture applications.
- Antibody Purification Using Protein A, Protein G, or Protein L Agarose
Protocols for batch antibody purification using Protein A, Protein G, or Protein L agarose.
- Antibody Purification Using Protein A-based Chromatography
Purification options using Protein A sepharose chromatography media, from binding to elution.
Related Categories
Knockout, knock-in, knockdown, or overexpress your targets with our CRISPR gene-editing tools.
Cell culture media for cell lines, primary cells, organoids, and advanced cell models.
Chromatography purification of antibodies for lab scale, process scale, and industrial scale.
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