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Merck
CN

W387509

Dimethyl sulfoxide

≥99%

Synonym(s):

DMSO

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About This Item

Linear Formula:
(CH3)2SO
CAS Number:
67-68-5
Molecular Weight:
78.13
Flavis number:
12.175
PubChem Substance ID:
24901911
UNSPSC Code:
12191502
FEMA Number:
3875
EC Number:
200-664-3
MDL number:
MFCD00002089
Beilstein/REAXYS Number:
506008

Key Documents

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Product Name

Dimethyl sulfoxide, ≥99%

InChI key

IAZDPXIOMUYVGZ-UHFFFAOYSA-N

InChI

1S/C2H6OS/c1-4(2)3/h1-2H3

SMILES string

CS(C)=O

biological source

synthetic

grade

Halal

agency

meets purity specifications of JECFA

vapor density

2.7 (vs air)

vapor pressure

0.42 mmHg ( 20 °C)

assay

≥99%

autoignition temp.

573 °F

shelf life

Expiration date period - 5 years

expl. lim.

42 %, 63 °F

color

colorless

refractive index

n20/D 1.479 (lit.)

bp

189 °C (lit.)
189 °C

mp

16-19 °C (lit.)

solubility

water: miscible

density

1.10 g/mL (lit.)

application(s)

flavors and fragrances

documentation

see Safety & Documentation for available documents

food allergen

no known allergens

organoleptic

butter; sulfurous

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Application

Dimethyl sulfoxide may be used in the synthesis of the following:
  • α, β−Unsaturated carbonyl sugar derivatives.
  • Conversion of secondary bromides or olefins to bromohydrin.
  • Synthesis of α-hydroxycarbonyls from corresponding ketones.
DMSO has been used to prepare the DMSO-phosphate buffer solution, which was used to dissolve the selective ETB (ET = endothelin) receptor antagonist in a study. It has been used for the preparation of nysatin solution.

Disclaimer

Supercools easily and remelts slowly at room temperature. Solidified product can be re-liquified by warming to room temperature without detriment to the product.

General description

Dimethyl sulfoxide (DMSO) is a hygroscopic, high polarity amphiphilic solvent with an ability to dissolve many compounds. Cytotoxic study of DMSO on the pulp tissue repair-related activity of odontoblast-like cells showed it produced minor effects. Along with phosphorus pentaoxide it participates in the oxidation of carbohydrates to afford aldosuloses and aldosiduloses. DMSO participates in the oxidation of some partially-acetylated carbohydrates followed by elimination to afford unsaturated, derivatives. Solubility of amylose and amylopectin in DMSO has been evaluated.

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
STBF3085V
STBF2208V
MKBR9662V
MKBS9028V
MKBS4349V

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Synthesis of α, β-unsaturated, carbonyl sugar derivatives by methyl sulfoxide oxidation and elimination.
Mackie DM and Perlin AS.
Carbohydrate Research, 24(1), 67-85 (1972)
From simple organobromides or olefins to highly value-added bromohydrins: a versatile performance of dimethyl sulfoxide.
Song S, et al.
Green Chemistry, 17(5), 2727-2731 (2015)
Cytotoxicity of dimethyl sulfoxide (DMSO) in direct contact with odontoblast-like cells.
Hebling J, et al.
Dental Materials : Official Publication of the Academy of Dental Materials, 31(4), 399-405 (2015)
David Jarriault et al.
Journal of visualized experiments : JoVE, (101)(101), e52652-e52652 (2015-08-15)
Analyzing the physiological responses of olfactory sensory neurons (OSN) when stimulated with specific ligands is critical to understand the basis of olfactory-driven behaviors and their modulation. These coding properties depend heavily on the initial interaction between odor molecules and the
Facile elimination accompanying some methyl sulfoxide oxidations. Formation of unsaturated carbohydrates.
Cree GM, et al.
Canadian Journal of Chemistry, 47(3), 513-515 (1969)
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