F5132
Factor II from human plasma
lyophilized powder, 5-20 units/mg protein
Synonym(s):
Prothrombin
form
lyophilized powder
specific activity
5-20 units/mg protein
UniProt accession no.
foreign activity
factor X <0.01% of base activity
thrombin, none detected
storage temp.
−20°C
Gene Information
human ... F2(2147)
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Biochem/physiol Actions
Plasma phospholipid binding protein; binds to endothelial cells, promotes clotting on the cell surfaces.
Preparation Note
When reconstituted with 1 ml of deionized water, solution will contain the indicated activity in 0.5 M NaCl, 0.05 M Tris-HCl, pH 8.0.
Other Notes
One unit is the amount contained in one mL of normal human plasma.
Regulatory Information
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Raúl H Morales-Borges
Puerto Rico health sciences journal, 31(4), 232-234 (2013-07-13)
Splenic infarction is rare and the prothrombin gene mutation (PGM) is not commonly observed in Puerto Rico. PGM is present in 1% of the general population, and in 7% of the people with deep venous thrombosis (DVT); it is found
G V Papatheodoridis et al.
Journal of hepatology, 31(4), 747-750 (1999-11-07)
We evaluated the efficacy of recombinant factor VII to correct impaired haemostasis in a patient with liver cirrhosis requiring an invasive procedure. A test intravenous bolus of 80 microg/kg of recombinant factor VII was given to a Jehovah's Witness, with
György Miklós Buzás
Orvosi hetilap, 154(21), 810-819 (2013-05-23)
Tumor markers are gene products which signal the occurrence of tumors in different organs as well as their response to surgery and chemotherapy. The discovery of tumor markers occurred after the demonstration of tumor-specific transplantation antigens in chemically or virally
Ayako Tomono et al.
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 110(5), 852-860 (2013-05-08)
A 78-year-old man was admitted for workup for a liver tumor. Both serum AFP and PIVKA-II levels were high (2260ng/ml and 806mAU/ml, respectively). Contrast-enhanced CT scan and MRI using Gd-EOB-DTPA demonstrated a liver tumor in segment 6 resembling the imaging
Maria M Aleman et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(8), 1829-1836 (2013-06-01)
Individuals with elevated prothrombin, including those with the prothrombin G20210A mutation, have increased risk of venous thrombosis. Although these individuals do not have increased circulating prothrombotic biomarkers, their plasma demonstrates increased tissue factor-dependent thrombin generation in vitro. The objectives of
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