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128910

N,O-Bis(trimethylsilyl)acetamide

synthesis grade, ≥95%

Synonym(s):

BSA

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About This Item

Linear Formula:
CH3C[=NSi(CH3)3]OSi(CH3)3
CAS Number:
10416-59-8
Molecular Weight:
203.43
UNSPSC Code:
12352103
NACRES:
NA.22
PubChem Substance ID:
24847878
EC Number:
233-892-7
Beilstein/REAXYS Number:
1306669
MDL number:
MFCD00008270
Assay:
≥95%
Form:
liquid
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grade

synthesis grade

Quality Segment

assay

≥95%

form

liquid

reaction suitability

reactivity: alcohol reactive, reactivity: amine reactive, reagent type: protection reagent

refractive index

n20/D 1.417 (lit.)

bp

71-73 °C/35 mmHg (lit.)

density

0.832 g/mL at 20 °C (lit.)

functional group

amine

SMILES string

C\C(O[Si](C)(C)C)=N/[Si](C)(C)C

InChI

1S/C8H21NOSi2/c1-8(9-11(2,3)4)10-12(5,6)7/h1-7H3/b9-8+

InChI key

SIOVKLKJSOKLIF-CMDGGOBGSA-N

General description

N,O-Bis(trimethylsilyl)acetamide(BSA) is a powerful silylating agent for the protection of amides, amines, alcohols, carboxylic acids, enols and phenols. It can also be used as a Bronsted base precursor in Tsuji–Trost reactions. Additionally, it can be used to activate different functional groups during the production of nucleosides, peptides, and heterocycles.

Application

Derivatization reagent for GC-MS analysis of phenolic acids in fruits.
Reagent for the regioselective desulfation of polysaccharide sulfates. Also used to prepare trimethylsilyl ethers of carbohydrates and alcohols.

Features and Benefits

BSA is good moisture absorbent.

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Signal Word

Danger

Hazard Codes

H226,H302,H314

Hazard Classifications

Acute Tox. 4 Oral - Flam. Liq. 3 - Skin Corr. 1B

supp_hazards

EUH014

Storage Class

3 - Flammable liquids

WGK

WGK 3

Flash Point (°F)

111.2 °F - closed cup

Flash Point (°C)

44 °C - closed cup

PPE (personal protective equipment)

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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