184225
Hydrogen fluoride pyridine
pyridine ~30 %, hydrogen fluoride ~70 %
Synonym(s):
HF-Pyridine, Olah′s reagent, PPHF, Poly(pyridine fluoride), Pyridine hydrofluoride, Pyridinium poly(hydrogen fluoride), Pyridinium polybifluoride
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About This Item
UNSPSC Code:
12352301
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4750151
form
liquid
Quality Level
composition
hydrogen fluoride, ~70% , pyridine, ~30%
density
1.1 g/mL at 20 °C (lit.)
storage temp.
−20°C
SMILES string
F[H].c1ccncc1
InChI
1S/C5H5N.FH/c1-2-4-6-5-3-1;/h1-5H;1H
InChI key
GRJJQCWNZGRKAU-UHFFFAOYSA-N
General description
May contain or form low levels of calcium fluoride during storage. Presence of this does not impact the specification values.
Application
Convenient form of anhydrous HF, stable up to 50°C. Has been used for the preparation of β-fluoroamines from amino alcohols and for the fluorination of acetylenes.
Used together with hypervalent iodine(III) reagents for ipso-fluorination of para-substituted phenols providing cyclohexadienones. Employed with Selectfluor® (Catalog No. 439479) for geminal fluorination of 2,2-diaryl-1,3-dithiolanes.
Used together with hypervalent iodine(III) reagents for ipso-fluorination of para-substituted phenols providing cyclohexadienones. Employed with Selectfluor® (Catalog No. 439479) for geminal fluorination of 2,2-diaryl-1,3-dithiolanes.
Reactant for preparation of:
Reagent for:
- Epimers of shikimic acid with the features of fucosylated glycans via zinc-mediated reductive ring opening followed by a Barbier reaction
- Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure
- Candidates for nucleic acid drugs
- ω-substituted gem-difluoroalkanes by oxidative desulfurization-difluorination
Reagent for:
- Halofluorination reactions
Legal Information
Selectfluor is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Eye Dam. 1 - Skin Corr. 1A
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Regulatory Information
监管及禁止进口产品
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Find documentation for the products that you have recently purchased in the Document Library.
Journal of Fluorine Chemistry, 37, 343-343 (1987)
Tetrahedron Letters, 32, 69-69 (1991)
Tetrahedron, 60, 6629-6629 (2004)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 184225-25G | 04061838756589 |
| 184225-100G | 04061838756572 |