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Merck
CN

224421

sec-Butylmagnesium chloride solution

2.0 M in diethyl ether

Synonym(s):

2-Butylmagnesium chloride, Chloro(1-methylpropyl)magnesium, sec-Butylchloromagnesium

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About This Item

Linear Formula:
CH3CH2CH(CH3)MgCl
CAS Number:
15366-08-2
Molecular Weight:
116.87
UNSPSC Code:
12352103
NACRES:
NA.22
PubChem Substance ID:
24853437
MDL number:
MFCD00000467
Beilstein/REAXYS Number:
3600265
Concentration:
2.0 M in diethyl ether

Key Documents

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InChI

1S/C4H9.ClH.Mg/c1-3-4-2;;/h3H,4H2,1-2H3;1H;/q;;+1/p-1

SMILES string

CCC(C)[Mg]Cl

InChI key

MJHZUYZQMNONPK-UHFFFAOYSA-M

reaction suitability

reaction type: Grignard Reaction

concentration

2.0 M in diethyl ether

density

0.828 g/mL at 25 °C

Quality Level

100

Related Categories

Application

sec-Butylmagnesium chloride solution is a Grignard reagent, it can be used in:
  • Metal catalyzed cross-coupling reactions with non-activated aryl chlorides.
  • The synthesis of various alkoxytrichlorosilanes by reacting with tetrachlorosilane and alcohols.

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Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3 - Water-react 1

target_organs

Central nervous system

supp_hazards

EUH019

Storage Class

4.3 - Hazardous materials which set free flammable gases upon contact with water

wgk

WGK 1

flash_point_f

-40.0 °F - closed cup

flash_point_c

-40 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SHBP2410
SHBN4731
SHBL6667
SHBH0096V
SHBG9461V

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35 years of palladium-catalyzed cross-coupling with Grignard reagents: how far have we come?
Knappke CEI and von Wangelin AJ
Chemical Society Reviews, 40(10), 4948-4962 (2011)
Versatile method for introduction of bulky substituents to alkoxychlorosilanes
Masaoka S, et al.
Journal of Organometallic Chemistry, 691(1-2), 182-192 (2006)
An unprecedented iron-catalyzed cross-coupling of primary and secondary alkyl Grignard reagents with non-activated aryl chlorides
Perry MC, et al.
Tetrahedron Letters, 53(33), 4436-4439 (2012)
Jee Myung Yang et al.
BMC ophthalmology, 17(1), 101-101 (2017-06-28)
Physical cooling of the eye surface relieves ocular discomfort, but translating this event to drug treatment of dry eye discomfort not been studied. Here, we synthesized a water-soluble TRPM8 receptor agonist called cryosim-3 (C3, 1-diisopropylphosphorylnonane) which selectively activates TRPM8 (linked

Articles

Selective Metalation and Additions

Transformative reagents enable selective conversions within molecules containing sensitive functionalities under mild reactions.

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