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Grignard Reagents

Grignard reagents are highly reactive organomagnesium halides formed by the reaction of magnesium metal with alkyl or alkenyl halides. They are very strong bases and react with acidic hydrogens such as alcohols, water and carboxylic acids. Our comprehensive portfolio of Grignard reagents, used in the Grignard reaction to form new carbon-carbon bonds, will make your breakthroughs feel closer than ever.

What is a Grignard reagent?

A Grignard reagent is an organomagnesium halide having a formula of RMgX, where X is a halogen (-Cl, -Br, or -I), and R is an alkyl or aryl (based on a benzene ring) group. To initiate a Grignard Reaction, a Grignard reagent is added to a ketone or aldehyde, to form a tertiary or secondary alcohol. The reaction with formaldehyde leads to a primary alcohol.

Grignard reagents can be used for determining the number of halogen atoms present in a halogen compound. Grignard degradation is used for the chemical analysis of certain triacylglycerols as well as many cross-coupling reactions for the formation of several carbon-carbon and carbon-heteroatom bonds. Industrially, the Grignard reaction is the key step in the production of Tamoxifen, which is used in the treatment of breast cancer.

Making a Grignard reagent

Grignard reagents are produced from the heated combination of halogenoalkane and magnesium in the presence of diethyl ether (ethoxyethane). The reaction should be kept dry to avoid the resulting Grignard reagent from reacting with water.

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Product Number

Product Name

Product Description

Pricing

225584

Vinylmagnesium bromide solution

1.0 M in THF

656984

Isopropylmagnesium chloride lithium chloride complex solution

1.3 M in THF

230111

Isopropylmagnesium chloride solution

2.0 M in THF

189901

Methylmagnesium chloride solution

3.0 M in THF

346152

Ethynylmagnesium bromide solution

0.5 M in THF

331376

Phenylmagnesium bromide solution

1.0 M in THF

171565

Phenylmagnesium bromide solution

3.0 M in diethyl ether

364649

tert-Butylmagnesium chloride solution

1.0 M in THF

703540

2,2,6,6-Tetramethylpiperidinylmagnesium chloride lithium chloride complex solution

1.0 M in THF/toluene

345113

Di-n-butylmagnesium solution

1.0 M in heptane

225908

Allylmagnesium chloride solution

2.0 M in THF

364673

Ethylmagnesium bromide solution

1.0 M in THF

224448

Phenylmagnesium chloride solution

2.0 M in THF

419567

Isopropenylmagnesium bromide solution

0.5 M in THF

775797

Isopropylmagnesium bromide solution

0.75 M in THF

225916

Benzylmagnesium chloride solution

2.0 M in THF

256021

(Trimethylsilyl)methylmagnesium chloride solution

1.0 M in diethyl ether

227234

2-Mesitylmagnesium bromide solution

1.0 M in THF

303828

Ethylmagnesium chloride solution

2.0 M in THF

291005

Butylmagnesium chloride solution

2.0 M in THF

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Related Product Resources

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Article: Selective Metalations using i-PrMgCl·LiCl and s-BuMgCl·LiCl
Aldrichimica Acta VOL. 41 NO.3: Green, Mild, And Versatile Synthetic Methods
Aldrichimica Acta VOL. 48 NO.2: Late Stage Functionalization
Aldrichimica Acta VOL. 48 NO.3: Spirocyclic Modules

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