287067
L-Proline methyl ester hydrochloride
98%, for peptide synthesis
Synonym(s):
(S)-Methyl pyrrolidine-2-carboxylate hydrochloride, L-Pro-OMe HCl
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About This Item
Empirical Formula (Hill Notation):
C6H11NO2 · HCl
CAS Number:
Molecular Weight:
165.62
NACRES:
NA.22
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
218-363-0
MDL number:
Beilstein/REAXYS Number:
3596045
Product Name
L-Proline methyl ester hydrochloride, 98%
Quality Level
assay
98%
form
solid
optical activity
[α]20/D −31°, c = 0.5 in H2O
reaction suitability
reaction type: solution phase peptide synthesis
mp
69-71 °C (lit.)
application(s)
peptide synthesis
SMILES string
Cl[H].[H][C@]1(CCCN1)C(=O)OC
InChI
1S/C6H11NO2.ClH/c1-9-6(8)5-3-2-4-7-5;/h5,7H,2-4H2,1H3;1H/t5-;/m0./s1
InChI key
HQEIPVHJHZTMDP-JEDNCBNOSA-N
Application
L-Proline methyl ester hydrochloride can be used as:
- A building block in peptide synthesis.
- A catalyst to synthesize 3,4-dihydropyrimidin-2-(1H)-ones via Biginelli condensation reaction with aryl aldehydes, methyl acetoacetate, and urea.
- A reactant to prepare prolylproline.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Studies on the Biginelli reaction: a mild and selective route to 3, 4-dihydropyrimidin-2 (1H)-ones via enamine intermediates
Mabry J and Ganem B
Tetrahedron Letters, 47(1), 55-56 (2006)
An efficient green synthesis of proline-based cyclic dipeptides under water-mediated catalyst-free conditions
Thajudeen H, et al.
Tetrahedron Letters, 51(9), 1303-1305 (2010)
Synthesis of Prolylproline
Gaidukevich VA, et al.
Russ. J. Org. Chem., 55(7), 1005-1008 (2019)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 287067-25G | 04061826265956 |
| 287067-1G | 04061826265949 |
| 287067-5G | 04061826265963 |