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367001

4,4′,4′′-Trimethoxytrityl chloride

technical grade

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About This Item

Linear Formula:
(CH3OC6H4)3CCl
CAS Number:
49757-42-8
Molecular Weight:
368.85
NACRES:
NA.22
PubChem Substance ID:
24862380
UNSPSC Code:
12352101
EC Number:
256-474-6
MDL number:
MFCD00008408
Form:
powder
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grade

technical grade

Quality Segment

form

powder

reaction suitability

reactivity: alcohol reactive, reactivity: amine reactive, reactivity: thiol reactive, reagent type: protection reagent

mp

146-148 °C (lit.)

functional group

chloro

SMILES string

COc1ccc(cc1)C(Cl)(c2ccc(OC)cc2)c3ccc(OC)cc3

InChI

1S/C22H21ClO3/c1-24-19-10-4-16(5-11-19)22(23,17-6-12-20(25-2)13-7-17)18-8-14-21(26-3)15-9-18/h4-15H,1-3H3

InChI key

OBFCMKPFILBCSQ-UHFFFAOYSA-N

Application

4,4′,4″-Trimethoxytrityl chloride can be used:
  • In one of the key synthetic steps for the preparation of two phosphoramidite building blocks.
  • To prepare protein tagging molecule (3-[tris(4-methoxyphenyl)methylsulfanyl]propanoic acid by reacting with thioacetic acid.
  • To prepare C-2 amino trimethoxytrityl substituted nucleoside, which is a key intermediate for the synthesis of nucleoside based capping agent.

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves

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