Key Documents

View All Documentation

404322

Dichloro(1,2-diaminocyclohexane)platinum(II)

Name: Dichloro(1,2-diaminocyclohexane)platinum(II)
Brand: ALDRICH

Synonym(s):

(1,2-Diaminocyclohexane)platinum(II) chloride

Select a Size

Change View

About This Item

Linear Formula:

[C₆H₁₀(NH₂)₂]PtCl₂

CAS Number:

52691-24-4

Molecular Weight:

380.17

NACRES:

NA.22

PubChem Substance ID:

24865237

UNSPSC Code:

12161600

MDL number:

MFCD00058826

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Quality Level

100

reaction suitability

core: platinum, reagent type: catalyst

mp

280 °C (dec.) (lit.)

SMILES string

Cl[Pt]Cl.NC1CCCCC1N

InChI

1S/C6H14N2.2ClH.Pt/c7-5-3-1-2-4-6(5)8;;;/h5-6H,1-4,7-8H2;2*1H;/q;;;+2/p-2

InChI key

PNNCIXRVXCLADM-UHFFFAOYSA-L

Description

pictograms

GHS08,GHS05

signalword

Danger

hcodes

H317,H318,H334,H341,H351,H360FD,H362,H372

pcodes

P260 - P263 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313

Hazard Classifications

Carc. 2 - Eye Dam. 1 - Lact. - Muta. 2 - Repr. 1B - Resp. Sens. 1B - Skin Sens. 1 - STOT RE 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Comparisons of tetrachloro(d,l-trans)1,2-diaminocyclohexane-platinum(IV) biotransformations in the plasma of Fischer 344 rats at therapeutic and toxic doses.

P F Carfagna et al.

Cancer chemotherapy and pharmacology, 27(5), 335-341 (1991-01-01)

Plasma biotransformations of tetrachloro(d,l-trans)1,2-diaminocyclohexaneplatinum(IV) (tetraplatin) were determined in vivo at both therapeutic (3 mg/kg) and toxic (12 mg/kg) doses in Fischer 344 rats. Tetraplatin was rapidly converted to dichloro(d,l-trans)1,2-diaminocyclohexaneplatinum(II) [PtCl2(dach)]. This conversion was complete at the earliest time measured (7.5

Cisplatin-DNA adducts inhibit ribosomal RNA synthesis by hijacking the transcription factor human upstream binding factor.

X Zhai et al.

Biochemistry, 37(46), 16307-16315 (1998-11-18)

Several eukaryotic cellular proteins recognize DNA modified by the anticancer drug cisplatin (cis-diamminedichloroplatinum(II) or cis-DDP); among these proteins is a class of DNA-binding molecules containing the HMG (high-mobility group) box DNA recognition motif. We have previously reported the extraordinarily high

Synthesis and cytotoxic activity of dextran carrying cis-dichloro(cyclohexane-trans-l-1,2-diamine)platinum(II) complex.

Y Ohya et al.

Journal of biomaterials science. Polymer edition, 7(12), 1085-1096 (1996-01-01)

cis-Dichloro(cyclohexane-trans-l-1,2-diamine)platinum(II) (Dach-Pt(chlorato)), is a platinum complex which is expected to exhibit higher antitumor activity than, and show no cross resistance with, cisplatin. However, its strong side-effects and low water-solubility have also been cited. We report that polymer/antitumor drug conjugates shows

View All Related Papers

Global Trade Item Number

SKU	GTIN
404322-500MG	04061831986808