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Merck
CN

404322

Dichloro(1,2-diaminocyclohexane)platinum(II)

Synonym(s):

(1,2-Diaminocyclohexane)platinum(II) chloride

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About This Item

Linear Formula:
[C6H10(NH2)2]PtCl2
CAS Number:
52691-24-4
Molecular Weight:
380.17
NACRES:
NA.22
PubChem Substance ID:
24865237
UNSPSC Code:
12161600
MDL number:
MFCD00058826

Key Documents

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InChI

1S/C6H14N2.2ClH.Pt/c7-5-3-1-2-4-6(5)8;;;/h5-6H,1-4,7-8H2;2*1H;/q;;;+2/p-2

SMILES string

Cl[Pt]Cl.NC1CCCCC1N

InChI key

PNNCIXRVXCLADM-UHFFFAOYSA-L

reaction suitability

core: platinum, reagent type: catalyst

mp

280 °C (dec.) (lit.)

Quality Level

100

Related Categories

pictograms

Health hazardCorrosion
GHS08,GHS05

signalword

Danger

Hazard Classifications

Carc. 2 - Eye Dam. 1 - Lact. - Muta. 2 - Repr. 1B - Resp. Sens. 1B - Skin Sens. 1 - STOT RE 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCS6465
MKCH0904
MKBX4372V
MKBS5387V
MKBD2991V

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Sachiko Kaida et al.
Cancer research, 70(18), 7031-7041 (2010-08-06)
Nanoparticle therapeutics are promising platforms for cancer therapy. However, it remains a formidable challenge to assess their distribution and clinical efficacy for therapeutic applications. Here, by using multifunctional polymeric micellar nanocarriers incorporating clinically approved gadolinium (Gd)-based magnetic resonance imaging contrast
Horacio Cabral et al.
Journal of controlled release : official journal of the Controlled Release Society, 101(1-3), 223-232 (2004-12-14)
Block copolymer micelles, containing dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt), the oxaliplatin parent complex, were prepared through polymer-metal complex formation of DACHPt with poly(ethylene glycol)-poly(glutamic acid) block copolymer [PEG-P(Glu)] in distilled water. By dynamic light scattering (DLS) measurement, the micelle size was determined to
Kensuke Osada et al.
Journal of the American Chemical Society, 134(32), 13172-13175 (2012-07-28)
Spontaneous formation of polymeric metallosomes with uniform size (~100 nm) was found to occur in aqueous medium through the reaction of an anticancer agent, (1,2-diaminocyclohexane)platinum(II) (DACHPt), with a Y-shaped block copolymer of ω-cholesteroyl-poly(L-glutamic acid) and two-armed poly(ethylene glycol) (PEGasus-PLGA-Chole). Circular
L M Ruiz-Perez et al.
Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 38(1), 45-48 (1987-03-01)
The trypanocidal activity of three new compounds derived of the antineoplastic drug cis-diamminodichloroplatinum(II) (DDP) has been studied over epimastigote forms of Trypanosoma cruzi. The electron microscopy indicated that, in the treated animals, the nuclear chromatin is distributed in the nucleus
C B Oswald et al.
Research communications in chemical pathology and pharmacology, 64(1), 41-58 (1989-04-01)
The disposition of 3H-cis-1,2-diaminocyclohexanedichloroplatinum (II) and 3H-cis-1,2-diaminocyclohexanemalonatoplatinum (II) was investigated in P388 tumor-bearing BDF1 mice. Fifteen minutes after IP administration of the drugs, the serum contained 12% of the 3H-chloride derivative and 20% of the malonate derivative. Both drugs distributed
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