404322
二氯（1,2-二氨基环己烷）铂（II）
别名:
(1,2-二氨基环己烷)氯化铂(II)
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关于此项目
线性分子式:
[C6H10(NH2)2]PtCl2
化学文摘社编号:
分子量:
380.17
MDL编号:
UNSPSC代码:
12161600
PubChem化学物质编号:
NACRES:
NA.22
质量水平
反应适用性
core: platinum
reagent type: catalyst
mp
280 °C (dec.) (lit.)
SMILES字符串
Cl[Pt]Cl.NC1CCCCC1N
InChI
1S/C6H14N2.2ClH.Pt/c7-5-3-1-2-4-6(5)8;;;/h5-6H,1-4,7-8H2;2*1H;/q;;;+2/p-2
InChI key
PNNCIXRVXCLADM-UHFFFAOYSA-L
警示用语：
Danger
危险分类
Carc. 2 - Eye Dam. 1 - Lact. - Muta. 2 - Repr. 1B - Resp. Sens. 1B - Skin Sens. 1 - STOT RE 1
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
X Zhai et al.
Biochemistry, 37(46), 16307-16315 (1998-11-18)
Several eukaryotic cellular proteins recognize DNA modified by the anticancer drug cisplatin (cis-diamminedichloroplatinum(II) or cis-DDP); among these proteins is a class of DNA-binding molecules containing the HMG (high-mobility group) box DNA recognition motif. We have previously reported the extraordinarily high
P F Carfagna et al.
Cancer chemotherapy and pharmacology, 27(5), 335-341 (1991-01-01)
Plasma biotransformations of tetrachloro(d,l-trans)1,2-diaminocyclohexaneplatinum(IV) (tetraplatin) were determined in vivo at both therapeutic (3 mg/kg) and toxic (12 mg/kg) doses in Fischer 344 rats. Tetraplatin was rapidly converted to dichloro(d,l-trans)1,2-diaminocyclohexaneplatinum(II) [PtCl2(dach)]. This conversion was complete at the earliest time measured (7.5
Y Ohya et al.
Journal of biomaterials science. Polymer edition, 7(12), 1085-1096 (1996-01-01)
cis-Dichloro(cyclohexane-trans-l-1,2-diamine)platinum(II) (Dach-Pt(chlorato)), is a platinum complex which is expected to exhibit higher antitumor activity than, and show no cross resistance with, cisplatin. However, its strong side-effects and low water-solubility have also been cited. We report that polymer/antitumor drug conjugates shows
A platinum(IV) complex oxidizes guanine to 8-oxo-guanine in DNA and RNA.
S Choi et al.
Inorganic chemistry, 40(22), 5481-5482 (2001-10-16)
Sachiko Kaida et al.
Cancer research, 70(18), 7031-7041 (2010-08-06)
Nanoparticle therapeutics are promising platforms for cancer therapy. However, it remains a formidable challenge to assess their distribution and clinical efficacy for therapeutic applications. Here, by using multifunctional polymeric micellar nanocarriers incorporating clinically approved gadolinium (Gd)-based magnetic resonance imaging contrast
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