404322
二氯（1,2-二氨基环己烷）铂（II）
别名:
(1,2-二氨基环己烷)氯化铂(II)
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关于此项目
线性分子式:
[C6H10(NH2)2]PtCl2
化学文摘社编号:
分子量:
380.17
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12161600
MDL number:
InChI
1S/C6H14N2.2ClH.Pt/c7-5-3-1-2-4-6(5)8;;;/h5-6H,1-4,7-8H2;2*1H;/q;;;+2/p-2
SMILES string
Cl[Pt]Cl.NC1CCCCC1N
InChI key
PNNCIXRVXCLADM-UHFFFAOYSA-L
reaction suitability
core: platinum, reagent type: catalyst
mp
280 °C (dec.) (lit.)
Quality Level
signalword
Danger
Hazard Classifications
Carc. 2 - Eye Dam. 1 - Lact. - Muta. 2 - Repr. 1B - Resp. Sens. 1B - Skin Sens. 1 - STOT RE 1
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
A platinum(IV) complex oxidizes guanine to 8-oxo-guanine in DNA and RNA.
S Choi et al.
Inorganic chemistry, 40(22), 5481-5482 (2001-10-16)
Sachiko Kaida et al.
Cancer research, 70(18), 7031-7041 (2010-08-06)
Nanoparticle therapeutics are promising platforms for cancer therapy. However, it remains a formidable challenge to assess their distribution and clinical efficacy for therapeutic applications. Here, by using multifunctional polymeric micellar nanocarriers incorporating clinically approved gadolinium (Gd)-based magnetic resonance imaging contrast
Kensuke Osada et al.
Journal of the American Chemical Society, 134(32), 13172-13175 (2012-07-28)
Spontaneous formation of polymeric metallosomes with uniform size (~100 nm) was found to occur in aqueous medium through the reaction of an anticancer agent, (1,2-diaminocyclohexane)platinum(II) (DACHPt), with a Y-shaped block copolymer of ω-cholesteroyl-poly(L-glutamic acid) and two-armed poly(ethylene glycol) (PEGasus-PLGA-Chole). Circular
L M Ruiz-Perez et al.
Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 38(1), 45-48 (1987-03-01)
The trypanocidal activity of three new compounds derived of the antineoplastic drug cis-diamminodichloroplatinum(II) (DDP) has been studied over epimastigote forms of Trypanosoma cruzi. The electron microscopy indicated that, in the treated animals, the nuclear chromatin is distributed in the nucleus
Horacio Cabral et al.
Journal of controlled release : official journal of the Controlled Release Society, 101(1-3), 223-232 (2004-12-14)
Block copolymer micelles, containing dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt), the oxaliplatin parent complex, were prepared through polymer-metal complex formation of DACHPt with poly(ethylene glycol)-poly(glutamic acid) block copolymer [PEG-P(Glu)] in distilled water. By dynamic light scattering (DLS) measurement, the micelle size was determined to
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