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47622

Fmoc-Thr(tBu)-OH

Name: Fmoc-Thr(tBu)-OH
Brand: ALDRICH

≥98.0% (HPLC), for peptide synthesis

Synonym(s):

Fmoc-O-tert-butyl-L-threonine

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₂₇NO₅

CAS Number:

71989-35-0

Molecular Weight:

397.46

NACRES:

NA.26

PubChem Substance ID:

57651042

eCl@ss:

32160406

UNSPSC Code:

12352209

EC Number:

276-261-1

MDL number:

MFCD00077075

Beilstein/REAXYS Number:

4581133

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Properties

Product Name

Fmoc-Thr(tBu)-OH, ≥98.0% (HPLC)

Quality Segment

100

assay

≥98.0% (HPLC)

optical activity

[α]20/D +16±1°, c = 1% in ethyl acetate

reaction suitability

reaction type: C-H Activation, reaction type: Fmoc solid-phase peptide synthesis, reagent type: ligand
reaction type: Peptide Synthesis

application(s)

peptide synthesis

functional group

Fmoc, amine, carboxylic acid

storage temp.

2-8°C

SMILES string

C[C@@H](OC(C)(C)C)[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O

InChI

1S/C23H27NO5/c1-14(29-23(2,3)4)20(21(25)26)24-22(27)28-13-19-17-11-7-5-9-15(17)16-10-6-8-12-18(16)19/h5-12,14,19-20H,13H2,1-4H3,(H,24,27)(H,25,26)/t14-,20+/m1/s1

InChI key

LZOLWEQBVPVDPR-VLIAUNLRSA-N

Description

General description

Fmoc-Thr(tBu)-OH also known as Fmoc-O-tert-butyl-L-threonine, is commonly used as amino acid building block in peptide synthesis.

Application

Fmoc-Thr(tBu)-OH can be used to synthesize chlorofusin analogues via solid phase peptide synthesis. Additionally, it can serve as a protecting group for both the amine and the hydroxyl functions in solid-phase synthesis of complex depsipeptides.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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