532282
2-Chlorotrityl chloride, polymer-bound
200-400 mesh, extent of labeling: 0.3-0.8 mmol/g Cl loading, 2 % cross-linked
Synonym(s):
2,α-Dichlorobenzhydryl-polystyrene crosslinked with divinylbenzene
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
CAS Number:
UNSPSC Code:
12352107
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1983914
Quality Level
crosslinking
2 % cross-linked
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
extent of labeling
0.3-0.8 mmol/g Cl loading
particle size
200-400 mesh
application(s)
peptide synthesis
SMILES string
Clc1ccccc1C(Cl)(c2ccccc2)c3ccccc3
InChI
1S/C19H14Cl2/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H
InChI key
JFLSOKIMYBSASW-UHFFFAOYSA-N
Application
- Acid labile resin used in Fmoc-based solid phase peptide synthesis.
- Mild acidic cleavage conditions lead to the release of the peptide acid where fully protected peptides can be released if desired.
- 2-Chlorotrityl chloride resins prevent racemization of the first amino acid and are thus very useful when racemic mixtures are forming (common with residues such as His or Cys).
- This resin also prevents diketopiperazide formation, which can be an issue with proline C-terminal peptide sequences.
Use:
- Attachment of the first amino acid residue is effected by stirring the resin, the protected amino acid, and excess diisopropylethylamine (DIEA) in dichloromethane.
- Cleavage of the final protected peptide fragment is achieved under very mild conditions using either acetic acid/trifluoroethanol (TFE)/dichloromethane (1:1:8; v/v/v), hexafluoroisopropanol (HFIP)/dichloromethane (1:4; v/v) or simply 0.5% trifluoroacetic acid/dichloromethane (v/v).
- Higher concentrations of TFA can be used if retention of peptide side chaing protecting groups is unimportant. Note that trityl chloride is moisture-sensitive, and, therefore, should be stored and handled appropriately.
- If the resin becomes deactivated, treatment with acetyl chloride or SOCl2 in toluene before use is recommended to restore its activity.
Still not finding the right product?
Explore all of our products under 2-Chlorotrityl chloride, polymer-bound
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Storage Class
11 - Combustible Solids
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 532282-5G | 04061833373163 |