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Merck
CN

561657

(1,3-Dioxan-2-ylethyl)magnesium bromide solution

0.5 M in THF

Synonym(s):

1,3-Dioxane - 2-ethyl- magnesium complex, [2-(1,3-Dioxan-2-yl)ethyl]magnesium bromide

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About This Item

Empirical Formula (Hill Notation):
C6H11BrMgO2
CAS Number:
Molecular Weight:
219.36
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352103
MDL number:
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reaction suitability

reaction type: Grignard Reaction

Quality Segment

packaging

Sure/Seal™ of

concentration

0.5 M in THF

bp

65 °C

density

0.951 g/mL at 25 °C

functional group

ether

storage temp.

2-8°C

SMILES string

Br[Mg]CCC1OCCCO1

InChI

1S/C6H11O2.BrH.Mg/c1-2-6-7-4-3-5-8-6;;/h6H,1-5H2;1H;/q;;+1/p-1

InChI key

JYNXRXBIEHSSLR-UHFFFAOYSA-M

Application

(1,3-Dioxan-2-ylethyl)magnesium bromide can be used:
  • In a Grignard addition-acylation method for the preparation of enamides.
  • To prepare trisubstituted allenes by reacting with propargylic ammonium salts.
  • In one of the key synthetic steps for the synthesis of febrifugine based antimalarial drugs.

Legal Information

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC
Product of Rieke Metals, Inc.
Rieke is a registered trademark of Rieke Metals, Inc.


supp_hazards

Storage Class

3 - Flammable liquids

Flash Point (°F)

No data available

Flash Point (°C)

No data available

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - STOT SE 3

Target Organs

Central nervous system, Respiratory system



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