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712191

COMU^®

Name: COMU<SUP>&#174;</SUP>
Brand: ALDRICH

≥96.5% (TLC), for peptide synthesis

Synonym(s):

(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₉F₆N₄O₄P

CAS Number:

1075198-30-9

Molecular Weight:

428.27

UNSPSC Code:

12352107

PubChem Substance ID:

329763117

NACRES:

NA.22

MDL number:

MFCD11975052

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Properties

Product Name

COMU^®, 97%

Quality Level

100

assay

≥96.5% (TLC), 96.5-103.5% (T), 97%

form

crystals

reaction suitability

reaction type: Coupling Reactions

greener alternative product characteristics

Less Hazardous Chemical Syntheses
Inherently Safer Chemistry for Accident Prevention
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

application(s)

peptide synthesis

functional group

amine, ester, ether, nitrile

greener alternative category

, Aligned

storage temp.

2-8°C

SMILES string

F[P-](F)(F)(F)(F)F.CCOC(=O)C(=NO\C(N1CCOCC1)=[N+](/C)C)C#N

InChI

1S/C12H19N4O4.F6P/c1-4-19-11(17)10(9-13)14-20-12(15(2)3)16-5-7-18-8-6-16;1-7(2,3,4,5)6/h4-8H2,1-3H3;/q+1;-1/b14-10-;

InChI key

GPDHNZNLPKYHCN-DZOOLQPHSA-N

Description

General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product is a Safer, non-explosive and more effective replacement for Benzotriazole-Based peptide coupling reagents and thus aligns with "Less Hazardous Chemical Synthesis" and "Inherently Safer Chemistry for Accident Prevention". Click here for more information.

Application

COMU – Safer and More Efficient Peptide Coupling Reagent

Advantages

Equal or even superior performance to HATU
Non-explosive (does not contain benzotriazole moiety)
Suitable for solution phase & solid phase peptide synthesis
Utmost retention of configuration – low to non-existent racemization
High solubility and stability in typical solvents
Visual or colorimetric reaction monitoring possible
Easy removal of water-soluble by-products

Morpholine-Based Immonium and Halogenoamidinium Salts as Coupling Reagents in Peptide Synthesis

Legal Information

COMU is a registered trademark of Luxembourg Bio Technologies Ltd.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Global Trade Item Number

SKU	GTIN
712191-100G	04061832843964
712191-25G	04061832844008
712191-5G	04061832844015