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Merck
CN

D9754

2-Aminoethyl diphenylborinate

97%

Synonym(s):

2-APB, 2-Aminoethoxydiphenyl borate, 2-Aminoethyl diphenyl borate, Diphenylboric acid 2-aminoethyl ester, Diphenylborinic acid, NSC 17107

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About This Item

Linear Formula:
(C6H5)2BOCH2CH2NH2
CAS Number:
524-95-8
Molecular Weight:
225.09
UNSPSC Code:
12352103
NACRES:
NA.22
PubChem Substance ID:
57654145
EC Number:
208-366-5
Beilstein/REAXYS Number:
2942273
MDL number:
MFCD00014823
Assay:
97%
Form:
powder

Key Documents

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description

Drug Control: Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet

Quality Level

200

assay

97%

form

powder

drug control

Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet

storage temp.

−20°C

SMILES string

NCCOB(c1ccccc1)c2ccccc2

InChI

1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2

InChI key

BLZVCIGGICSWIG-UHFFFAOYSA-N

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Application

Reactant for:
  • Preparation of apoptotic inducers

  • Activator of the Orai3 (ORAI calcium release-activated calcium modulator 3) protein
  • Inhibits Ca2+ influx through transient receptor potential 2 channels in rat dorsal root ganglion neurons
  • Membrane-permeable SOCE (store operated calcuym entry) inhibitor

Biochem/physiol Actions

Membrane-permeable modulator of intracellular IP3-induced calcium release.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN8363
BCCN1316
BCCL3896
BCCM4346
BCCM1318

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Akinobu Z Suzuki et al.
Bioorganic & medicinal chemistry letters, 20(4), 1395-1398 (2010-01-26)
Store-operated calcium entry (SOCE) is an important mechanism for replenishing intracellular calcium stores and for sustaining calcium signaling. We developed a method for synthesis of bisboron compounds that have two borinic acids or their esters in one molecule. These compounds
Mustafa Nazıroğlu et al.
The Journal of membrane biology, 241(2), 69-75 (2011-04-22)
Exposure to oxidative stress causes health problems, including sensory neuron neuropathy and pain. Rotenone is a toxin used to generate intracellular oxidative stress in neurons. However, the mechanism of toxicity in dorsal root ganglion (DRG) neurons has not been characterized.
T Maruyama et al.
Journal of biochemistry, 122(3), 498-505 (1997-11-05)
The effects of a novel membrane-penetrable modulator, 2APB (2-aminoethoxy diphenyl borate), on Ins(1,4,5)P3-induced Ca2+ release were examined. 2APB inhibited Ins(1,4,5)P3-induced Ca2+ release from rat cerebellar microsomal preparations without affecting [3H]Ins(1,4,5)P3 binding to its receptor. The IC50 value (concentration producing 50%
Velasco-Bejarano, B.; et al.
Synlett, 921-921 (2007)
Samuel Shin et al.
Cellular signalling, 67, 109484-109484 (2019-11-27)
Oxidative stress and reactive oxygen species (ROS) generation can be influenced by G-protein coupled receptor (GPCR)-mediated regulation of intracellular Ca2+ ([Ca2+]i) signaling. ROS production are much higher in proximal tubular (PT) cells; in addition, the lack of antioxidants enhances the
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Global Trade Item Number

SKUGTIN
D9754-5G04061835556670
D9754-10G04061835556649
D9754-1G04061835556656
D9754-25G04061835556663

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