G6201
Glycine
reagent grade, 98%
Synonym(s):
Aminoacetic acid, Aminoethanoic acid, Glycocoll
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About This Item
Linear Formula:
NH2CH2COOH
CAS Number:
Molecular Weight:
75.07
EC Number:
200-272-2
UNSPSC Code:
12352209
MDL number:
Beilstein/REAXYS Number:
635782
grade
reagent grade
assay
98%
pKa (25 °C)
(1) 2.35, (2) 9.60, 2.35
mp
240 °C (dec.) (lit.)
SMILES string
NCC(O)=O
InChI
1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChI key
DHMQDGOQFOQNFH-UHFFFAOYSA-N
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Biochem/physiol Actions
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
Storage Class
13 - Non Combustible Solids
wgk
WGK 1
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Maria Luisa Gelmi et al.
Journal of medicinal chemistry, 50(9), 2245-2248 (2007-04-07)
New 3-O-glycosyl-3-demethylthiocolchicines containing natural and unnatural sugar moieties were prepared and tested on gamma-aminobutyric acid (GABA) and strychnine-sensitive glycine receptors present in rat brain and spinal cord. Two different synthetic approaches were used with the readily available 3-O-demethylthiocolchicine (1b) and
Maria Luisa Gelmi et al.
Journal of medicinal chemistry, 49(18), 5571-5577 (2006-09-01)
A novel class of 3-demethoxy-3-glycosylaminothiocolchicines (7) was prepared and tested for muscle relaxant activity. The syntheses were performed starting from the new 3-amino-3-demethoxythiocolchicine (5) prepared in good yield from 3-O-demethylthiocolchicine (1c) using the Buchwald-Hartwig reaction. The condensation of 5 with
Guifeng Kang et al.
Bioorganic & medicinal chemistry letters, 20(20), 6157-6160 (2009-05-24)
Aimed at the chemotherapy of chronic pain two kinds of analgesic pharmacophores, substituted purine and Gly-AA-OBzl, were coupled via a five-step-reaction procedure and 19 novel conjugates N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycylamino acid benzylesters were provided. On mouse-tail flick model their in vivo analgesic activities
Hillary E Hoffman et al.
Journal of medicinal chemistry, 52(19), 6032-6041 (2009-10-02)
Mammalian serine racemase (SR) is a pyridoxal-5'-phosphate (PLP) dependent enzyme responsible for the biosynthesis of the neurotransmitter D-serine, which activates N-methyl-D-aspartate (NMDA) receptors in the CNS. Aberrant regulation of NMDA receptor signaling has been implicated in a variety of neuropathologies
Anders A Jensen et al.
Journal of medicinal chemistry, 50(19), 4616-4629 (2007-08-29)
The pharmacological properties of bisquaternary caracurine V, iso-caracurine V, and pyrazino[1,2-a;4,5-a']diindole analogues and of the neuromuscular blocking agents alcuronium and toxiferine I have been characterized at numerous ligand-gated ion channels. Several of the analogues are potent antagonists of the homomeric
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